DB01154ApprovedVet approvedSmall molecule
A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The... (From Martindale, The Extra Pharmacopoeia, 30th ed, p919).
- Mechanism
- Curator reviewed
Thiamylal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
- Primary indication
- Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state.Curator reviewed
- Formula / weight
- C12H18N2O2S · 254.349 g/mol (avg)
Resolves to
Clinical / RWD
Structure
InChIKey
XLOMZPUITCYLMJ-UHFFFAOYSA-NSMILESCCCC(C)C1(CC=C)C(=O)NC(=S)NC1=OWhat you can answer from here — as of September 23, 2026
4Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Thiamylal, and which of those have an active Phase 3 trial?
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