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Displaying results 4871 - 4880 of 10000 in total
  1. Target

    UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimerase

    go.drugbank.com/bio_entities/BE0002630
    TargetPseudomonas aeruginosa

    Polypeptides: UDP-N-acetyl-alpha-D-glucosaminouronate 4-epimeraseSynonyms: UDP-GlcNAcA 4-epimerase
  2. Target

    C-type lectin domain family 4 member E

    go.drugbank.com/bio_entities/BE0009096
    TargetHumans

    Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity). … The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491).

    Polypeptides: C-type lectin domain family 4 member E
  3. Target

    C-type lectin domain family 4 member C

    go.drugbank.com/bio_entities/BE0010522
    TargetHumans

    Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). … May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283)

    Polypeptides: C-type lectin domain family 4 member C
  4. Drug

    Hydroxyzine

    go.drugbank.com/drugs/DB00557
    ApprovedInvestigational

    Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties. … [A1257,A187589] It was first developed in 1955,[A189726] and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus

    Mixtures: DOLMARAL®Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  5. Drug

    Buserelin

    go.drugbank.com/drugs/DB06719
    ApprovedInvestigational

    Buserelin is a synthetic peptide analog of the luteinizing hormone-releasing hormone (LHRH) agonist, which stimulates the pituitary gland's gonadotrophin-releasing hormone receptor (GnRHR). … It is used in prostate cancer treatment.

    Products: SUPREFACT INJECTABLE 1 mg/ml, Suprefact 1 mg/ml Durchstechflasche
  6. Indication

    Previously treated with an HCV regimen containing an NS5A inhibitor Chronic hepatitis C genotype 4

    go.drugbank.com/conditions/DBCOND0093777
    Drugs: Voxilaprevir
    Synonyms: Previously treated with an HCV regimen containing an NS5A inhibitor Chronic hepatitis C genotype 4
  7. Drug

    Sulpiride

    go.drugbank.com/drugs/DB00391
    ApprovedWithdrawn

    [A229538] Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather than positive symptoms at low doses, though the effects are more equal at higher doses. … Sulpiride first appeared in published literature in 1967.

    Mixtures: NEUPAX DUO-SCategories: MATE 1 Substrates, MATE 2 Substrates
  8. Drug

    Clonidine

    go.drugbank.com/drugs/DB00575
    ApprovedInvestigational

    Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD. … [L7237,L54536,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]

    Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexSynonyms: 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine, 2-((2,6-Dichlorophenyl)imino)imidazolidine
  9. Drug

    Certolizumab pegol

    go.drugbank.com/drugs/DB08904
    ApprovedInvestigational

    [A176585] It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. … [A176606] It was developed and manufactured by UCB Pharma, first FDA approved in 2008[L45018] and updated for a new indication on March 28, 2019.[L5819]

    Products: CİMZİA 200 MG/ML S.C. ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR (2 ADET), CIMZIA 200 MG ILO IN FER
  10. Drug

    Fluorescein

    go.drugbank.com/drugs/DB00693
    ApprovedInvestigational

    A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal … It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)

    Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 3-RingSynonyms: D&C Yellow No. 7, 9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenone