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Acenocoumarol
go.drugbank.com/drugs/DB01418ApprovedInvestigationalAcenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, IX and X, and ...
Synonyms: 3-(alpha-Acetonyl-p-nitrobenzyl)-4-hydroxycoumarin, 3-(alpha-(p-Nitrophenol)-beta-acetylethyl)-4-hydroxycoumarinCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesTestosterone propionate
go.drugbank.com/drugs/DB01420ApprovedInvestigationalVet approvedWithdrawnTestosterone propionate is a slower-releasing anabolic steroid with a short half-life. It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of testosterone. Testosterone propionate was devel...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesMidomafetamine
go.drugbank.com/drugs/DB01454IllicitInvestigationalAn N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy. It is a widely abused drug...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates5-androstenedione
go.drugbank.com/drugs/DB01456ExperimentalIllicit5-androstenedione is a prohormone of testosterone. In the United States, the Controlled Substance Act is inclusive to anabolic steroids and their precursors. Thus 5-androstenedione is a controlled substance, and its use in athletes is pr...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCathine
go.drugbank.com/drugs/DB01486ExperimentalIllicitCathine, also known as d-norpseudoephedrine and (+)-norpseudoephedrine, is a psychoactive drug with stimulant properties. It belongs to the phenethylamine and amphetamine chemical classes.
Synonyms: D-Cathine, d-Nor-psi-ephedrineCategories: Cytochrome P-450 CYP2A6 Inhibitors, Cytochrome P-450 CYP3A InhibitorsSulfamethazine
go.drugbank.com/drugs/DB01582ApprovedVet approvedWithdrawnA sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.
Synonyms: (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin, 2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidineRoflumilast
go.drugbank.com/drugs/DB01656ApprovedInvestigationalRoflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme expressed on nearly all immune and pro-inflammatory cells, in addition to ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesLeuprolide
go.drugbank.com/drugs/DB00007ApprovedInvestigationalUnlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three
Octreotide
go.drugbank.com/drugs/DB00104ApprovedInvestigationalAcromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the f...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InhibitorsEnfuvirtide
go.drugbank.com/drugs/DB00109ApprovedInvestigationalEnfuvirtide is a 36 amino acid biomimetic peptide that is structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and subsequent intracellular uptake. The first agent in the novel class...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 Substrates