Sulfamethazine is an antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. A sulfanilamide anti-infective agent.
- Mechanism
- Curator reviewed
Sulfonamides inhibit the enzymatic conversion of pteridine and p-aminobenzoic acid (PABA) to dihydropteroic acid by competing with PABA for binding to dihydrofolate synthetase, an intermediate of tetrahydrofolic acid (THF) synthesis. THF is required for the synthesis of purines and dTMP and inhibition of its synthesis inhibits bacterial growth. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, another step in THF synthesis, and therefore act synergistically with the sulfonamides.
- Primary indication
- For the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections.Curator reviewed · 6 structured indications
- Formula / weight
- C12H14N4O2S · 278.33 g/mol (avg)
- First approval
- Canada, 1959
- Also known as
- Sulfadimethyldiazine · Sulfadimethylpyrimidine · Sulfadimidine · Sulfamezathine · Sulphadimethylpyrimidine
- Code names
- BN-2409 · NSC-67457 · NSC-683529
Resolves to
ASWVTGNCAZCNNR-UHFFFAOYSA-NSMILESCC1=CC(C)=NC(NS(=O)(=O)C2=CC=C(N)C=C2)=N1What you can answer from here — as of September 23, 2026
Which drugs share a target with Sulfamethazine, and which of those have an active Phase 3 trial?
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