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PSN357
go.drugbank.com/drugs/DB05044ExperimentalPSN357 is a glycogen phosphorylase inhibitor (GPI), which is designed to rapidly lower blood glucose levels by preventing glycogen breakdown to glucose in the liver.
Rolicyclidine
go.drugbank.com/drugs/DB01549ExperimentalIllicitBecause of its pharmacodynamic similarity to the drug phencyclidine (PCP), rolicyclidine was added to the Schedule I list of illegal drugs in the USA in the 1970s. … Rolicyclidine (PCPy) is classified as a dissociative anesthetic agent. It also has hallucinogenic and sedative properties.
Synonyms: 1-(1-phenylcyclohexyl)pyrrolidineCategories: Heterocyclic Compounds, 1-RingNOV-002
go.drugbank.com/drugs/DB05393InvestigationalNOV-002, the lead compound acts as a chemoprotectant and an immunomodulator, in combination with chemotherapy. … NOV-002 is approved and marketed in the Russian Fereration by Pharma BAM under the trade name Glutoxim.
ADL 10-0101
go.drugbank.com/drugs/DB05443ExperimentalBecause ADL 10-0101 does not cross the blood-brain barrier and enter the brain when administered at therapeutic doses, it is expected to avoid central nervous system side effects. … ADL 10-0101 is a peripheral kappa opioid agonist analgesic product candidate.
Dimethyltryptamine
go.drugbank.com/drugs/DB01488IllicitInvestigationalAn N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. … It apparently acts as an agonist at some types of serotonin receptors and an antagonist at others.
Synonyms: N,N-dimethyl-1H-indole-3-ethylamine, N,N-dimethyltryptamineCategories: Heterocyclic Compounds, 2-Ring, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSurotomycin
go.drugbank.com/drugs/DB12076InvestigationalSurotomycin is non-inferior to vancomycin and offers a promising alternative for the treatment and prevention of C. diff infection. … It is a benzenebutanoic acid derivative patented by Cubist Pharmaceuticals, Inc. as antibacterial agents for the treatment of Gram-positive infections.
Cefapirin
go.drugbank.com/drugs/DB01139ApprovedVet approvedCefapirin (INN, also spelled cephapirin), commonly marketed under the trade name Cefadyl, is a first-generation cephalosporin antibiotic that is available in injectable formulations. … Production for use in humans has been discontinued in the United States. Cefapirin is partly plasma-bound and is effective against gram-negative and gram-positive organisms.
Synonyms: (6R,7R)-3-(acetoxymethyl)-8-oxo-7-{[(pyridin-4-ylsulfanyl)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidCategories: Heterocyclic Compounds, 2-RingIR501
go.drugbank.com/drugs/DB06464ExperimentalIR501 (Ravax) is a potential first-in-class vaccine for the treatment of Rheumatoid Arthritis. It specifically targets autoreactive T-cells, reducing their activity. … It was last known to be in phase III clinical trials.
Lufotrelvir
go.drugbank.com/drugs/DB16514InvestigationalPF-07304814 is a small molecule prodrug that targets the 3CL<sup>pro</sup> protease (M<sup>pro)</sup>, which is used by viruses like SARS-CoV-2 to assemble and multiply[L31718]. … Once administered through intravenous infusion, the compound is cleaved into PF-00835231 to exert its anti-viral effects[L31718].
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingRivanicline
go.drugbank.com/drugs/DB05855ExperimentalRivanicline (TC-2403, RJR-2403, (E)-metanicotine) is a partial agonist at neuronal nicotinic acetylcholine receptors, binding primarily to the α4β2 subtype. … It was originally developed as a potential treatment for Alzheimer's disease for its nootropic effects but has also been found to inhibit the production of Interleukin-8.
Synonyms: (E)-metanicotine, (3E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amineCategories: Heterocyclic Compounds, 1-Ring