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Cocarboxylase
go.drugbank.com/drugs/DB01987ApprovedInvestigationalThe coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
Categories: Vitamin B Complex, Heterocyclic Compounds, 1-RingADH-1
go.drugbank.com/drugs/DB05485InvestigationalPoorly differentiated, highly invasive carcinomas are characterized by over-expression of N-cadherin (as opposed to E-cadherin). … ADH-1 is currently in clinical development in a combination program with a range of chemotherapeutic agents to investigate the synergistic effects noted in our preclinical models.
Synonyms: l-cysteinamide, n-acetyl-l-cysteinyl-l-histidyl-l-alanyl-l-valyl-, cyclic (1-5)-disulfideDesmethylprodine
go.drugbank.com/drugs/DB01478ExperimentalIllicitIt has been listed as a Schedule I controlled drug in the United States, and thus is not used clinically. It is known to be a designer drug, synthesized in 1977, for the purpose of recreational use. … Desmethylprodine, a derivative of meperidine, is an opioid analgesic with the potency of morphine.
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Heterocyclic Compounds, 1-RingSynonyms: 1-Methyl-4-phenyl-4-piperidinol propionate, 1-Methyl-4-phenyl-4-propionoxypiperidineAgrostis gigantea top
go.drugbank.com/drugs/DB14757ApprovedWithdrawnAgrostis gigantea top is the flowering part of the Agrostis gigantea plant. Agrostis gigantea top is mainly used in allergenic testing.
Dabigatran
go.drugbank.com/drugs/DB14726ApprovedInvestigationalDabigatran is the active form of the orally bioavailable prodrug [dabigatran etexilate].
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingEdetate disodium anhydrous
go.drugbank.com/drugs/DB14600ApprovedInvestigationalVet approvedEdetate disodium anhydrous is a polyvalent chelating agent used to treat hypercalcemia and digitalis toxicity associated ventricular arrhythmias.[A204275]
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsEcabet
go.drugbank.com/drugs/DB05265InvestigationalEcabet is a prescription eye drop for the treatment of dry eye syndrome. … Ecabet represents a new class of molecules that increases the quantity and quality of mucin produced by conjunctival goblet cells and corneal epithelia.
Categories: Pepsin A, antagonists & inhibitors, Compounds used in a research, industrial, or household settingAP5280
go.drugbank.com/drugs/DB05112ExperimentalAP5280 is a novel N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound platinum (Pt) therapeutic designed to increase the therapeutic index relative to conventional, small-molecule platinum agents.
Ezogabine
go.drugbank.com/drugs/DB04953ApprovedWithdrawnEzogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. … FDA approved in June 10, 2011 under the name of ezogabine.
Synonyms: N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester, ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamateRagweed pollen extract
go.drugbank.com/drugs/DB05368ApprovedWithdrawnThe company has initiated a phase III trial with its product for oral immunotherapy of ragweed allergy. … While traditional disease-modifying immunotherapeutics are administered by subcutaneous injection, Curalogic has developed a more convenient orally administered drug.