Search

Displaying results 4961 - 4970 of 10000 in total
  1. Drug

    Diaminopyrimidine oxide

    go.drugbank.com/drugs/DB18756
    Approved

    Diaminopyrimidine oxide is a compound similar to [minoxidil] which is used to aid in hair growth.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 2,4-diaminopyrimidine 3-n-oxide, 2,4-pyrimidinediamine, 3-oxide
  2. Drug

    Rivanicline

    go.drugbank.com/drugs/DB05855
    Experimental

    Rivanicline (TC-2403, RJR-2403, (E)-metanicotine) is a partial agonist at neuronal nicotinic acetylcholine receptors, binding primarily to the α4β2 subtype. … It was originally developed as a potential treatment for Alzheimer's disease for its nootropic effects but has also been found to inhibit the production of Interleukin-8.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: (E)-metanicotine, (3E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amine
  3. Drug

    Rolicyclidine

    go.drugbank.com/drugs/DB01549
    ExperimentalIllicit

    Because of its pharmacodynamic similarity to the drug phencyclidine (PCP), rolicyclidine was added to the Schedule I list of illegal drugs in the USA in the 1970s. … Rolicyclidine (PCPy) is classified as a dissociative anesthetic agent. It also has hallucinogenic and sedative properties.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-(1-phenylcyclohexyl)pyrrolidine
  4. Drug

    ADL 10-0101

    go.drugbank.com/drugs/DB05443
    Experimental

    Because ADL 10-0101 does not cross the blood-brain barrier and enter the brain when administered at therapeutic doses, it is expected to avoid central nervous system side effects. … ADL 10-0101 is a peripheral kappa opioid agonist analgesic product candidate.

  5. Drug

    CX501

    go.drugbank.com/drugs/DB05174
    Investigational

    Cx501 is used to treat epidermolysis bullosa (EB), a rare genetic condition which can lead to contraction of the joints, fusion of fingers and toes, contraction of the mouth membranes and narrowing of … the oesophagus.

  6. Drug

    Levocabastine

    go.drugbank.com/drugs/DB01106
    Approved

    Levocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastine was discovered at Janssen Pharmaceutica in 1979.

    Categories: Heterocyclic Compounds, 1-Ring
  7. Drug

    Mersalyl

    go.drugbank.com/drugs/DB09338
    Experimental

    Mersalyl is the sodium salt form of mersalyl acid, a mercurial diuretic. It is an outdated drug, and its approval has been discontinued by the FDA. … The sodium salt of a mercury-containing derivative of salicylamide, was formerly used (often in combination with theophylline) to treat edema, due to its powerful diuretic properties [L1577].

  8. Drug

    QRX-411

    go.drugbank.com/drugs/DB17868
    Experimental

    It addresses the underlying cause of Usher syndrome due to the c.7595-2144A>G mutation in the _USH2A_ gene.[L46777] … QRX-411 is a first-in-class RNA-based oligonucleotide designed to restore wild-type USH2A mRNA, leading to the production of the functional USH2A protein.

  9. Drug

    Rindopepimut

    go.drugbank.com/drugs/DB05374
    Investigational

    The vaccine consists of the EGFRv3-specific peptide (a 13-amino acid mutant vIII epitope) conjugated to the non-specific immunomodulator keyhole limpet hemocyanin (KLH). … The US FDA granted it Breakthrough Therapy Designation for glioblastoma in Feb 2015.

  10. Drug

    Medrysone

    go.drugbank.com/drugs/DB00253
    Approved

    Medrysone is a corticosteroid used in ophthalmology.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 11beta-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione