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LErafAON
go.drugbank.com/drugs/DB04973Investigationalor chemotherapy. … Phase I/II trials commenced in March 2001 and were ongoing as of June 2003.
Alvespimycin
go.drugbank.com/drugs/DB12442InvestigationalAlvespimycin is a derivative of geldanamycin and heat shock protein (HSP) 90 inhibitor. It has been used in trials studying the treatment of solid tumor in various cancer as an antitumor agent. … In comparison to the first HSP90 inhibitor tanespimycin, it exhibits some pharmacologically desirable properties such as reduced metabolic liability, lower plasma protein binding, increased water solubility
Adrafinil
go.drugbank.com/drugs/DB08925ApprovedWithdrawnIt is also been used off-label to prevent fatigue or falling asleep for extended periods of time. Adrafinil does not currently have FDA approval and is thus unregulated in the United States. … It was marketed in France and elsewhere in Europe under the trade name Olmifon until September 2011 when France's FDA equivalent reassessed the drug and withdrew marketing permission.
OXI-4503
go.drugbank.com/drugs/DB05143Investigationalto an orthoquinone chemical species that has direct cytotoxic effects on tumor cells. … Preclinical studies have demonstrated that OXI-4503 has (i) single-agent activity against a range of xenograft tumor models; and (ii) synergistic or additive effects when incorporated in various combination
Acellular nerve allograft
go.drugbank.com/drugs/DB30293ApprovedInvestigationalOur team is working on the full update, which will be available soon. [L54673,L54668] … Approved by the FDA under a Biologics License Application (BLA) as an acellular nerve scaffold for the treatment of adult and pediatric patients (aged ≥1 month) with sensory, mixed, and motor peripheral
Chlorophyll A
go.drugbank.com/drugs/DB02133ExperimentalCategories: Heterocyclic Compounds with 4 or More RingsSinapultide
go.drugbank.com/drugs/DB11332ApprovedWithdrawn[L2502] This protein has a weight of 2469.40. … [L2505] Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in preterm infants.
Ukrain cation
go.drugbank.com/drugs/DB17150ExperimentalCategories: Heterocyclic Compounds with 4 or More RingsBarnidipine
go.drugbank.com/drugs/DB09227InvestigationalUsed in the treatment of hypertension, barnidipine displays high affinity for the calcium channels of the smooth muscle cells in the vascular wall [L1131] and selectivity against cardiovascular L-type … The active component is composed of a single optical isomer (*3'S, 4S* configuration), which is the most potent and longest-acting of the four enantiomers [A31567].
Chromium Cr-51
go.drugbank.com/drugs/DB11140ApprovedInvestigationalChromium Cr-51 is an isotope of chromium that has been used as a radioactive label for decades. … It is used as a diagnostic radiopharmaceutical agent in nephrology to determine glomerular filtration rate,[A249765,A249770] and in hematology to determine red blood cell volume or mass, study the red