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Valoctocogene roxaparvovec
go.drugbank.com/drugs/DB15561ApprovedInvestigationalWithdrawnValoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). … [A252797] As opposed to these therapies, valoctocogene roxaparvovec offers the advantage of continuous and measurable steady-state levels of coagulation factor VIII.[A252807]
Categories: Blood Coagulation Factors, Recombinant ProteinsSynonyms: DNA (synthetic adeno-associated virus 5 vector BMN 270 human blood-coagulation factor VIII SQ variant-specifying)Mecasermin rinfabate
go.drugbank.com/drugs/DB14751ApprovedInvestigationalMecasermin rinfabate is similar to [DB01277] in that both drugs contain recombinant DNA origin insulin-like growth factor 1 (IGF-1). … Mecasermin rinfabate however, is already bound to recombinant DNA origin insulin-like growth factor binding protein 3 (IGFBP-3)[A12605].
Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsSynonyms: Recombinant human insulin-like growth factor-I/insulin-like growth factor binding protein-3, Mecasermin rinfabate recombinantCoagulation factor XIa
go.drugbank.com/drugs/DB15420InvestigationalCoagulation factor XIa is under investigation in clinical trial NCT01701947 (HEMOLEVEN® Expanded Access Program Prevention of Surgical/Postpartum Hemorrhage Severe Inherited Factor XI Deficiency).
Categories: Blood Coagulation Factors, Factor XISynonyms: Human coagulation factor XI, Coagulation factor XIaAlbumin human
go.drugbank.com/drugs/DB00062ApprovedInvestigationalThis is a biosimilar drug to existing human serum albumin and was approved for a biological license at both 5% and 25% concentrations by the FDA on June 21, 2018 [L3101]. … Human albumin is a small globular protein (molecular weight: 66.5 kDa), consisting of a single chain of 585 amino acids organized in three repeated homolog domains (sites I, II, and III).
Synonyms: Albumin human, Albumin (human)Mixtures: Albumin Human Diluent, UMAN SERUMEthanol
go.drugbank.com/drugs/DB00898ApprovedInvestigationalIt is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. … A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant.
Mixtures: Welly Human Repair Kit, Alcohol in DextroseCategories: Alcohols, Antiseptics and DisinfectantsNesiritide
go.drugbank.com/drugs/DB04899ApprovedInvestigationalWithdrawnNesiritide is a 32 amino acid recombinant human B-type natriuretic peptide. … Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing).
Categories: Amino Acids, Peptides, and Proteins, Hormones, Hormone Substitutes, and Hormone AntagonistsSynonyms: Human brain natriuretic factor-32, Nesiritide recombinantHuman thrombin
go.drugbank.com/drugs/DB11571ApprovedInvestigationalIn particular, while human thrombin products are made from pooled human source plasma, recombinant thrombin is a human coagulation protein produced via recombinant DNA technology from a genetically modified … This transformation mimics the final coagulation cascade step which involves the clotting mass that adheres to the wound surface and achieves hemostasis and sealing of open tissues.
Synonyms: Human thrombin, Thrombin humanMixtures: EVICEL Fibrin Sealant (Human) Solution, 50-90 mg/ml, 800-1200 IU/ml, EVICEL Fibrin Sealant (Human)Marstacimab
go.drugbank.com/drugs/DB17725ApprovedInvestigational[A264608] Marstacimab is used to prevent bleeding episodes in patients with hemophilia,[L51803] which is an X‐linked bleeding disorder characterized by coagulation clotting factor deficiency. … Marstacimab is a human monoclonal immunoglobulin G Type 1 (IgG1) antibody produced by Chinese hamster ovary (CHO) cells by recombinant DNA technology.
Categories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsSynonyms: Immunoglobulin g1-lambda, anti-(human tissue factor pathway inhibitor (tfpi, extrinsic pathway inhibitor, epi, lipoprotein-associated coagulation inhibitor, laci)), Immunoglobulin g1, anti-(human tissue factor pathway inhibitor) (human monoclonal pf-06741086 .gamma.1-chain), disulfide with human monoclonal pf-06741086 .lambda.-chain, dimerConestat alfa
go.drugbank.com/drugs/DB09228ApprovedIt does this through inhibition of several target proteases within these pathways including activated C1s, kallikrein, factor XIIa and factor XIa. … C1 esterase inhibitor has also been shown to inhibit the action of thrombin within the coagulation pathway, and tPA and plasmin within the fibrinolytic pathway.
Categories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsSynonyms: Recombinant human C1-INH, Recombinant human C1 inhibitorInsulin human
go.drugbank.com/drugs/DB00030ApprovedInvestigationalHuman insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. … Human Insulin is a 51 residue peptide hormone produced by recombinant DNA technology by inserting the human insulin gene into Escherichia coli bacteria or Saccharomyces cerevisiae.
Synonyms: Insulin recombinant human, Insulin recombinant purified humanSalts: Insulin human zinc suspension