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Casdatifan
go.drugbank.com/drugs/DB21701InvestigationalCasdatifan is under investigation in clinical trial NCT07000149 (A Study to Investigate the Efficacy and Safety of Volrustomig ± Casdatifan vs Nivolumab + Ipilimumab as 1L Treatment for Advanced ccRCC)
Diphenidol
go.drugbank.com/drugs/DB01231ApprovedWithdrawnDiphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children.
Exagamglogene autotemcel
go.drugbank.com/drugs/DB15572ApprovedInvestigational[L49231] It is the first CRISPR-based gene editing therapy to be approved in the United States.
Alphameprodine
go.drugbank.com/drugs/DB01499ExperimentalIllicitThe stereoisomer betameprodine is similarly classified, however alphameprodine is more widely used (both are referred to as Meprodine). Alphameprodine is a structural analogue of meperidine.
Betameprodine
go.drugbank.com/drugs/DB01552ExperimentalIllicitThe stereoisomer alphameprodine is similarly classified, and was more widely used (both are referred to as Meprodine). Betameprodine is a structural analogue of meperidine.
Gaboxadol
go.drugbank.com/drugs/DB06554InvestigationalGaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck, who reported increased deep sleep without the reinforcing
Esmirtazapine
go.drugbank.com/drugs/DB06678InvestigationalEsmirtazapine, known by the standardized identifier SCH 900265, was under development by Organon to treat insomnia and vasomotor symptoms associated with menopause.
Osanetant
go.drugbank.com/drugs/DB04872InvestigationalThis follows an earlier decision to discontinue development of eplivanserin for schizophrenia.
Plosaracetam
go.drugbank.com/drugs/DB21594InvestigationalPlosaracetam is under investigation in clinical trial NCT05199142 (A Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SDI-118 in Elderly Male and Female Study Participants With Cognitive
Icalcaprant
go.drugbank.com/drugs/DB21651InvestigationalIcalcaprant is under investigation in clinical trial NCT06696755 (A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder