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Displaying results 5111 - 5120 of 9322 in total
  1. Drug

    Orludodstat

    go.drugbank.com/drugs/DB21498
    Investigational

    The usage of the INN stem '-dodstat' in the name indicates that Orludodstat is a dihydro-orotate dehydrogenase (DHODH) inhibitor. … Orludodstat is under investigation in clinical trial NCT03404726 (A Study to Investigate BAY2402234, a Dihydroorotate Dehydrogenase (DHODH) Inhibitor, in Myeloid Malignancies).

  2. Drug

    Radequinil

    go.drugbank.com/drugs/DB19722
    Investigational

    The usage of the INN stem '-nil' in the name indicates that Radequinil is a benzodiazepine receptor antagonist/agonist. … Radequinil is under investigation in clinical trial NCT00359944 (Safety and Efficacy Study of AC-3933 in Adults With Mild to Moderate Alzheimer's Disease).

  3. Drug

    Linseed oil

    go.drugbank.com/drugs/DB11357
    Investigational

    Linseed oil is particularly susceptible to polymerization reactions upon exposure to oxygen in air due to a high content of di- and triunsaturated esters. … Linseed oil is a rich source of α-Linolenic acid extracted from the dried, ripened seeds of the flax plant *Linum usitatissimum*.

  4. Drug

    Oxandrolone

    go.drugbank.com/drugs/DB00621
    ApprovedInvestigational

    A synthetic hormone with anabolic and androgenic properties.

  5. Drug

    AVI-4557

    go.drugbank.com/drugs/DB05447
    Experimental

    Studies indicate that AVI-4557 can successfully reduce the rate of metabolism for certain drugs, therefore allowing greater and longer availability of the drug in the patient's system through a decrease … AVI-4557 is an oral antisense compound that selectively inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of approximately half of currently

  6. Drug

    KER-047

    go.drugbank.com/drugs/DB19111
    Investigational

    KER-047 is under investigation in clinical trial NCT05927012 (A Study to Evaluate the Safety and Preliminary Efficacy of a Response-guided Dose Titration of KER-047 in the Treatment of Functional IDA (

  7. Drug

    GPI-1485

    go.drugbank.com/drugs/DB05814
    Investigational

    GPI 1485 is a product candidate that belongs to a class of small molecule compounds called neuroimmunophilin ligands. … In preclinical experiments, neuroimmunophilin ligands have been shown to repair and regenerate damaged nerves without affecting normal, healthy nerves.

  8. Drug

    Zeranol

    go.drugbank.com/drugs/DB11478
    ExperimentalVet approved

    It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. … It is 3-4x more potent as an estrogen agonist than the related compound zearalenone.

  9. Drug

    RGX-181

    go.drugbank.com/drugs/DB17942
    Experimental

    RGX-181 consists of an adeno-associated virus serotype 9 (AAV9) vector designed to deliver the soluble lysosomal enzyme tripeptidyl peptidase I (TPP1) gene. … Developed by REGENXBIO, it is being investigated for the treatment of late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease.[L47072]

  10. Drug

    Zebularine

    go.drugbank.com/drugs/DB03068
    Experimental

    It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. … Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.