Zebularine

DB03068ExperimentalSmall molecule

A chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also... Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

Chemical structure of Zebularine
Formula / weight
C9H12N2O5 · 228.202 g/mol (avg)
Also known as
4-deoxyuridine
Code names
NSC-309132

Resolves to

Structure
InChIKeyRPQZTTQVRYEKCR-WCTZXXKLSA-NSMILESOC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC=NC1=O
Targets

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
2+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Zebularine, and which of those have an active Phase 3 trial?

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