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Displaying results 5181 - 5190 of 8010 in total
  1. Drug

    Melperone

    go.drugbank.com/drugs/DB09224
    Investigational

    Melperone has been used for a span of greater than 30 years in the European Union [L1316].

  2. Target

    Cytochrome P450 1A1

    go.drugbank.com/bio_entities/BE0009369
    EnzymeRat

    Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha … Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (By similarity). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:20972997).

    Synonyms: Cytochrome P450 form 6
  3. Drug

    Debamestrocel

    go.drugbank.com/drugs/DB17934
    Investigational

    Debamestrocel is under clinical development by BrainStorm Cell Therapeutics and is being investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).[L47266]

  4. Drug

    Proscillaridin

    go.drugbank.com/drugs/DB13307
    Experimental

    Proscillaridin is a cardiac glycoside that is derived from plants of the genus Scilla and in Drimia maritima (Scilla maritima).

    Categories: Compounds used in a research, industrial, or household setting
  5. Drug

    Pimicotinib

    go.drugbank.com/drugs/DB18972
    Investigational

    Pimicotinib is under investigation in clinical trial NCT05804045 (Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)). … It was initially developed by Abbisko Therapeutics Co in collaboration with Merck KGaA. [L53748] Pimicotinib was granted Fast Track Designation in December 2023 by the FDA. [L53753]

  6. Target

    Cytochrome P450 2C8

    go.drugbank.com/bio_entities/BE0002887
    TargetEnzymeHumans

    It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316) … Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772).

    Synonyms: Cytochrome P450 form 1
  7. Drug

    Dichlorophen

    go.drugbank.com/drugs/DB11396
    InvestigationalVet approved

    It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from dogs and cats.

  8. Drug

    Tritoqualine

    go.drugbank.com/drugs/DB13711
    Approved

    Categories: Antihistamines for Systemic Use
  9. Drug

    AVI-5126

    go.drugbank.com/drugs/DB05726
    Investigational

    AVI-526 is an improved formulation of [AVI-4557], developed for use on Vein Grafts before use in Heart by-Pass Graft Surgery. … AVI-526 works by silencing a gene known as c-myc, a key regulatory gene involved in cardiovascular restenosis.

  10. Drug

    Verzistobart

    go.drugbank.com/drugs/DB18895
    Investigational

    Verzistobart is under investigation in clinical trial NCT06056895 (Triple Immune Checkpoint Inhibition for Advanced or Metastatic PD-(L)1 Refractory Merkel Cell Carcinoma).