Melperone is an atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients. Melperone is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol.
- Mechanism
- Curator reviewed · 3 references
Melperone demonstrates antagonist activity at D2 dopaminergic and 5HT2A serotonergic receptors. It has a weak affinity to D2 receptors and possesses less risk of inducing dopamine receptor supersensitivity after both acute and chronic administration. In addition, the ratio of dopamine D4/D2 occupancy for melperone has been shown to resemble the binding profile of clozapine.
- Primary indication
- For the treatment of schizophrenia, sleep, disorders, agitation and mentally confused states.Curator reviewed · 6 structured indications
- Formula / weight
- C16H22FNO · 263.356 g/mol (avg)
- Code names
- FG-5111
Resolves to
DKMFBWQBDIGMHM-UHFFFAOYSA-NSMILESCC1CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1What you can answer from here — as of July 17, 2026
Which drugs share a target with Melperone, and which of those have an active Phase 3 trial?
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