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Displaying results 511 - 520 of 2256 in total
  1. Target

    Melanocortin receptor 3

    go.drugbank.com/bio_entities/BE0009683
    TargetHumans

    G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8463333).

    Polypeptides: Melanocortin receptor 3Function: corticotropin receptor activity
  2. Target

    Asialoglycoprotein receptor 1

    go.drugbank.com/bio_entities/BE0010188
    TargetCarrierTransporterHumans

    Upon ligand binding, the receptor-ligand complex is internalized and trafficked to a sorting organelle, where dissociation occurs. The receptor is then recycled back to the cell surface … Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway (PubMed:25485912).

    Polypeptides: Asialoglycoprotein receptor 1Function: asialoglycoprotein receptor activity
  3. Target

    GABA(B) Receptor

    go.drugbank.com/bio_entities/BE0010194
    Target

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase ( … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2Synonyms: GABA-B receptor 1, GABA-B receptor 2
  4. Target

    Interleukin-21 receptor

    go.drugbank.com/bio_entities/BE0010657
    TargetHumans

    This is a receptor for interleukin-21

    Polypeptides: Interleukin-21 receptorSynonyms: IL-21 receptor, Novel interleukin receptor
  5. Target

    Neuromedin-B receptor

    go.drugbank.com/bio_entities/BE0013104
    TargetHumans

    Receptor for neuromedin-B (PubMed:1655761). … Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity)

    Polypeptides: Neuromedin-B receptorSynonyms: Neuromedin-B-preferring bombesin receptor
  6. Target

    Interleukin-23 receptor

    go.drugbank.com/bio_entities/BE0015564
    TargetHumans

    Associates with IL12RB1 to form the interleukin-23 receptor.

    Polypeptides: Interleukin-23 receptorSynonyms: IL-23 receptor
  7. Target

    Discoidin domain receptor

    go.drugbank.com/bio_entities/BE0027487
    TargetHumans

    Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. … It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation.

    Polypeptides: Discoidin domain-containing receptor 2, Epithelial discoidin domain-containing receptor 1Synonyms: Discoidin domain receptor 2, Discoidin receptor tyrosine kinase
  8. Target

    Interleukin-2 receptor

    go.drugbank.com/bio_entities/BE0027978
    TargetHumans

    Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. … Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

    Polypeptides: Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit alphaSynonyms: IL-2 receptor subunit gamma, IL-2 receptor subunit alpha
  9. Drug

    Pretomanid

    go.drugbank.com/drugs/DB05154
    ApprovedInvestigational

    Research in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy regimens.

  10. Drug

    Mupirocin

    go.drugbank.com/drugs/DB00410
    ApprovedInvestigationalVet approved

    Mupirocin, formerly termed pseudomonic acid A, is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. Produced by fermentation using the organism Pseudomonas fluorescens, mu...