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Displaying results 511 - 520 of 10000 in total
  1. Drug

    1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE

    go.drugbank.com/drugs/DB07652
    Experimental

    Synonyms: 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE
  2. Drug

    Triclosan

    go.drugbank.com/drugs/DB08604
    Approved

    An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. … It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards

    Mixtures: KURSEPT %19 + %1 KREM (30 G), Nail MDCategories: Phenol and Derivatives, Antiseptics and Disinfectants
  3. Drug

    5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine

    go.drugbank.com/drugs/DB08163
    Experimental

    Synonyms: 5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine
  4. Drug

    Cefotetan

    go.drugbank.com/drugs/DB01330
    ApprovedInvestigational

    The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. … A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly.

    Synonyms: (6R,7S)-7-(4-(carbamoylcarboxymethylene)-1,3-dithiethane-2-carboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5- yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2- carboxylic acidCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  5. Drug

    Sildenafil

    go.drugbank.com/drugs/DB00203
    ApprovedInvestigational

    In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850 … Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in

    Mixtures: DAPOXIL 30/50 MG FILM KAPLI TABLET,18 FILM KAPLI TABLET, DAPOKSEL 30 MG/50 MG FILM TABLET ,3 FILM TABLETCategories: Phosphodiesterase 5 Inhibitors, P-glycoprotein inhibitors
  6. Drug

    Idelalisib

    go.drugbank.com/drugs/DB09054
    ApprovedInvestigational

    By inhibiting this enzyme, idelalisib induces apoptosis of malignant cells and inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and C-X-C chemokine receptors type 5 and … type 4 signalling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow.

    Categories: Antineoplastic and Immunomodulating Agents, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one, 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one
  7. Drug

    Valrubicin

    go.drugbank.com/drugs/DB00385
    Approved

    Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. … It is a semisynthetic analog of the [doxorubicin], which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.

    Categories: Anthracyclines and Related Substances, Antineoplastic and Immunomodulating AgentsSynonyms: (8S, 10S)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione 8²-valerate, 2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl]ethyl pentanoate
  8. Drug

    Ceftaroline fosamil

    go.drugbank.com/drugs/DB06590
    ApprovedInvestigational

    Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections

    Synonyms: (6R,7R)-7-[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateCategories: Heterocyclic Compounds, 2-Ring
  9. Drug

    Zalcitabine

    go.drugbank.com/drugs/DB00943
    ApprovedWithdrawn

    This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. … A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen.

    Categories: Heterocyclic Compounds, 1-Ring, Nucleic Acids, Nucleotides, and NucleosidesSynonyms: 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one, 2',3'-Dideoxycytidine
  10. Drug

    Lamivudine

    go.drugbank.com/drugs/DB00709
    ApprovedInvestigational

    It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). … A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring.

    Mixtures: TRIUMEQ® 50 MG / 600 MG / 300 MG, TRIUMEQ 50 MG/600 MG/300 MG FILM KAPLI TABLET,90 FILM KAPLI TABLETCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates