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Displaying results 5241 - 5250 of 10000 in total
  1. Drug

    Piclozotan

    go.drugbank.com/drugs/DB12361
    Investigational

    Piclozotan has been investigated for the treatment of Parkinson's Disease.

    Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT1 Receptor Agonists
  2. Drug

    Vestronidase alfa

    go.drugbank.com/drugs/DB12366
    ApprovedInvestigational

    Vestronidase alfa, or vestronidase alfa-vjbk, is a recombinant human lysosomal beta glucuronidase that is a purified enzyme produced by recombinant DNA technology in a Chinese hamster ovary cell line. … The enzyme is a homotetramer consisted of 4 monomers with 629 amino acids, and holds the same amino acid sequence as human beta-glucuronidase (GUS) [FDA Label].

  3. Drug

    AZD-3839

    go.drugbank.com/drugs/DB12368
    Investigational

    AZD3839 has been used in trials studying the basic science of Safety, Tolerability, Alzheimer's Disease, and Blood Concentration.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  4. Drug

    Sotrastaurin

    go.drugbank.com/drugs/DB12369
    Investigational

    Sotrastaurin has been used in trials studying the basic science and treatment of Uveal Melanoma, Richter Syndrome, Prolymphocytic Leukemia, Recurrent Mantle Cell Lymphoma, and Recurrent Small Lymphocytic Lymphoma, among others.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  5. Drug

    Apricoxib

    go.drugbank.com/drugs/DB12378
    Investigational

    Apricoxib has been used in trials studying the treatment and prevention of Lung Cancer, Breast Cancer, Pancreatic Cancer, Non Small Cell Lung Cancer, and Metastatic Pancreatic Cancer, among others.

    Categories: Heterocyclic Compounds, 1-Ring
  6. Drug

    Merestinib

    go.drugbank.com/drugs/DB12381
    Investigational

    Merestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  7. Drug

    OSI-027

    go.drugbank.com/drugs/DB12387
    Investigational

    OSI-027 has been used in trials studying the treatment of Any Solid Tumor or Lymphoma.

    Synonyms: CYCLOHEXANECARBOXYLIC ACID, 4-(4-AMINO-5-(7-METHOXY-1H-INDOL-2-YL)IMIDAZO(5,1-F)(1,2,4)TRIAZIN-7-YL)-, TRANS-Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Evocalcet

    go.drugbank.com/drugs/DB12388
    Investigational

    Evocalcet has been used in trials studying the treatment of Hyperparathyroidism and Secondary Hyperparathyroidism.

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    Seladelpar

    go.drugbank.com/drugs/DB12390
    ApprovedInvestigational

    Seladelpar is a peroxisome proliferator-activated receptor (PPAR)-delta (δ) agonist. Seladelpar is a single enantiomer of the R-configuration. … [L51149] On August 14, 2024, seladelpar was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis,[L51154] which is a condition associated with aberrant bile acid metabolism

    Synonyms: (R)-2-(4-((2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)-THIO)-2-METHYLPHENOXY)ACETIC ACID, ((4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENYL)OXY)ACETIC ACIDCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  10. Drug

    Sagopilone

    go.drugbank.com/drugs/DB12391
    Investigational

    It is a so-called fully synthetic epothilone and is the first such compound to be in clinical development to combat several forms of cancer. … Epothilones are 16-member ring macrolides with antimicrotubule activity that share a similar mechanism of action to the taxanes but have demonstrated potent antiproliferative activity in several different

    Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 1-Ring