Merestinib

DB12381InvestigationalSmall molecule

Merestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.

Mechanism: Pharmacologically active on Hepatocyte growth factor receptor
Curator reviewed
Formula / weight: C₃₀H₂₂F₂N₆O₃ · 552.5309 g/mol (avg)
Code names: LY-2801653

Resolves to

Compound

UNII5OGS5K699ECAS1206799-15-6ChEMBLCHEMBL3545307PubChem44603533

Structure

InChIKeyQHADVLVFMKEIIP-UHFFFAOYSA-NSMILESCN1N=CC2=CC(OC3=C(F)C=C(NC(=O)C4=CC=C(C)N(C4=O)C4=CC=C(F)C=C4)C=C3)=C(C=C12)C1=CNN=C1

Targets

P08581MET

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

39Drug interactionsStructured to mechanism, not free text

11Clinical trialsPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Merestinib, and which of those have an active Phase 3 trial?

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