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Displaying results 5311 - 5320 of 10000 in total
  1. Drug

    Resiquimod

    go.drugbank.com/drugs/DB06530
    Investigational

    It is also being studied to find out if adding it to a tumor vaccine improves the antitumor immune response. It is a type of imidazoquinoline and a type of immunomodulator. … A substance being studied in the treatment of some types of skin cancer. When put on the skin, resiquimod causes some immune cells to make certain chemicals that may help them kill tumor cells.

    Categories: Heterocyclic Compounds, 1-Ring
  2. Drug

    Galidesivir

    go.drugbank.com/drugs/DB11676
    Investigational

    [L12039,L12084] Phase 1 clinical trials have begun to determine the safety of this drug in humans. … [L12042] Because of its activity against other coronaviruses, it may be studied as a potential therapy for COVID-19.

    Synonyms: Immucillin A, Immucillin-ACategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  3. Drug

    AZD3409

    go.drugbank.com/drugs/DB04893
    Experimental

    As of February 2007 the development of AZD3409 had been discontinued. … AZD3409 is a farnesyl-transferase inhibitor (FAR) indicated for the treatment of solid tumors. Phase I trials were initiated January 2003, and were ongoing as of February 2004.

    Categories: Heterocyclic Compounds, 1-Ring
  4. Drug

    Erythroxylum catuaba bark

    go.drugbank.com/drugs/DB14300
    Investigational

    "Catuaba" is a general term for a medicinal infusion created by the bark of plants belonging to the _Erythroxylum_ genus, though this name is also applied to infusions of plants belonging to other genera … [A215262] The infusion is thought to carry stimulant and aphrodisiac effects,[A215262] and catuaba made specifically with _Trichilia catigua_ has been investigated for use in depression.[A215267]

  5. Drug

    Zorecimeran

    go.drugbank.com/drugs/DB15843
    Investigational

    The CVnCov Vaccine (or CV07050101) is in development by CureVac AG. … As of June 2020, the company received regulatory approval from German and Belgian Authorities to commence Phase 1 clinical trials of this vaccine (NCT04449276).

  6. Drug

    Flucytosine

    go.drugbank.com/drugs/DB01099
    ApprovedInvestigational

    A fluorinated cytosine analog that is used as an antifungal agent.

    Synonyms: 5-FC, 5-FluorocytosineCategories: Heterocyclic Compounds, 1-Ring
  7. Drug

    Plitidepsin

    go.drugbank.com/drugs/DB04977
    Investigational

    Aplidine is a peptide found in tunicates which shows promise in shrinking tumors in pancreatic, stomach, bladder, and prostate cancers. The specific marine organism is _Aplidium albicans_. … Aplidine is also of interest as a potential treatment for some leukemias.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesSynonyms: Dehydrodidemnin B
  8. Drug

    Egaptivon pegol

    go.drugbank.com/drugs/DB05202
    Investigational

    Egaptivon pegol, formerly known as ARC1779, is a therapeutic aptamer antagonist of the A1 domain of von Willebrand Factor (vWF), the ligand for receptor glycoprotein 1b on platelets. … [A3290, A259053] Egaptivon pegol is a therapeutic oligonucleotide ("aptamer") which blocks the binding of the A1 domain of vWF to the platelet GPIb receptor, thereby modulating platelet adhesion, activation

  9. Drug

    LX201

    go.drugbank.com/drugs/DB04943
    Investigational

    LX201 is a silicone matrix ocular implant that provides sustained release of cyclosporine A (CsA) locally to the eye over the course of one year. … LX201 is implanted subconjunctivally (beneath the transparent membrane covering the white of the eye) in a minimally invasive procedure.

  10. Drug

    Zalutumumab

    go.drugbank.com/drugs/DB12202
    Investigational

    Zalutumumab is a fully human IgG1 monoclonal antibody designed to bind with selectivity to the epidermal growth factor receptor (EGFR). … Zalutumumab has been investigated for the treatment of Squamous Cell Cancer and Head and Neck Cancer.