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Hydrocortisone
go.drugbank.com/drugs/DB00741ApprovedInvestigationalVet approved[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574] … [L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.
Synonyms: Reichstein's substance M, 4-pregnen-11β,17α,21-triol-3,20-dioneInternational brands: Polcort H, Preparation H Hydrocortisone CreamEltrombopag
go.drugbank.com/drugs/DB06210ApprovedInvestigationalITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. … Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: REVOLADE® TABLETAS 25 MG, ROMPAG 25 MG FİLM KAPLI TABLET, 28 ADETSilodosin
go.drugbank.com/drugs/DB06207ApprovedInvestigationalSilodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder … neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenoceptors in the prostate.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: FENANTA® 8 MG, FENANTA® 4 MGNateglinide
go.drugbank.com/drugs/DB00731ApprovedApproximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. … It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.
Mixtures: NATMET 120/1000 MG TEDAVI PAKETI, 90+90 ADET, NATMET 120/500 MG TEDAVI PAKETI, 90+90 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesInterferon beta-1a
go.drugbank.com/drugs/DB00060ApprovedInvestigationalHuman interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced.
Categories: Interferon Type I, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: Interferon beta 1-a, IFN β-1aRoxadustat
go.drugbank.com/drugs/DB04847ApprovedInvestigationalRoxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. … It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that stimulates red blood cell production in response to low oxygen levels.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: Ernevod 20 mg Film Kaplı Tablet (12 adet), EVRENZO 20 MG FİLM KAPLI TABLET, 12 ADETDarbepoetin alfa
go.drugbank.com/drugs/DB00012ApprovedInvestigationalHuman erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
Products: NESP INJECTION PLASTIC SYRINGE 20 ?g/0.5 ml, ARANESP® 20 MCG SOLUCIÓN INYECTABLEPhentermine
go.drugbank.com/drugs/DB00191ApprovedIllicitInvestigationalPhentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug. … [A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to obtain the desired effect.[A174373]
Categories: Cytochrome P-450 Substrates, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesProducts: PANBESY CAPSULE 30 mg, PANBESY CAPSULE 15 MGFesoterodine
go.drugbank.com/drugs/DB06702ApprovedFesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: TOVIAZ 4 MG, FOSETAZ 4 MG UZATILMIŞ SALIMLI FİLM KAPLI TABLET, 28 ADETAzathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigational[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214] … Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesSynonyms: 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine, 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine