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Cenobamate
go.drugbank.com/drugs/DB06119ApprovedInvestigational[L10653] Cenobamate was granted FDA approval on 21 November 2019.[L10653] … [A188442,L10653] The exact mechanism of action has not been described in the literature, though it positively modulates GABA<sub>A</sub> and inhibits voltage gated sodium channels.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersProducts: XCOPRI TITRATION PACK 12.5 mg, 25 mg, XCOPRI TITRATION PACK 50 mg, 100 mgAbiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigationalAbiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-Pyridyl)androsta-5,16-dien-3beta-olPancrelipase
go.drugbank.com/drugs/DB00085ApprovedInvestigational[L2509] The pancrelipase mixture was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and FDA approved on April 12, 2010. … Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.
Mixtures: PANLIPAZ 170/80 MG ENTERİK KAPLI FİLM TABLET, 20 ADET, PANKREOFLAT 170/310 MG GRANÜL (22x2 g poşet)Products: FESTAL N 220 MG ENTERİK KAPLI TABLET, 20 ADET, FESTAL N 220 MG ENTERİK KAPLI TABLET, 100 ADETAluminum hydroxide
go.drugbank.com/drugs/DB06723ApprovedInvestigationalIt is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin.
Mixtures: แม๊ก 2, DICLOFENACO SÓDICO 100 MG - HIDROXIDO DE ALUMINIO GEL EQUIVALENTE A200 MGProducts: ALU-TAB TABLET 600 MG, ACTAL TABLET 216 mgPirfenidone
go.drugbank.com/drugs/DB04951ApprovedInvestigationalPirfenidone is a synthetic pyridone drug. … [A251370] It is an antifibrotic agent with anti-inflammatory and antioxidant properties [A251370] that is used to treat idiopathic pulmonary fibrosis (IPF),[L26801] which is a chronic, progressive form
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: ESBRİET 267 MG FİLM KAPLI TABLET, 21 TABLET, ESBRIET® CÁPSULAS DURAS 267 MGLercanidipine
go.drugbank.com/drugs/DB00528ApprovedInvestigationalWithdrawnLercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Mixtures: LERCAPREL 20 MG/10 MG, ZANIPRESS 20 MG/20 MG FILM TABLET,90 ADETCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingPeginterferon alfa-2b
go.drugbank.com/drugs/DB00022ApprovedInvestigationalWhen combined together, Peginterferon alfa-2b and [Ribavirin] have been shown to achieve a SVR between 41% for genotype 1 and 75% for genotypes 2-6 after 48 weeks of treatment. … -2b for the treatment of Hepatitis C [A19593].
Categories: peginterferon alfa-2b, peginterferon alfa-2b, combinationsSynonyms: PEG-IFN-α-2b, Pegylated Interferon α-2bLacidipine
go.drugbank.com/drugs/DB09236ApprovedIt is available as once-daily oral tablets containing 2 or 4 mg of the active compound commonly marketed as Lacipil or Motens. It is not currently FDA-approved. … In randomised, well-controlled trials, administration of daily single-dose lacidipine ranging from 2-6 mg demonstrated comparable antihypertensive efficacy similar to that of other long-acting dihydropyridine
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: LACIPIL 4 MG FILM KAPLI TABLET, 28 ADET, LACIPIL TABLET 4 mgAzilsartan medoxomil
go.drugbank.com/drugs/DB08822ApprovedInvestigationalIt is also available in a combination product with [chlorthalidone]. … It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in February 2011.
Mixtures: EDARBYCLOR (TABLETS) 40 MG/12.5 MG, EDARBYCLOR (TABLETS) 40 MG/12.5 MGCategories: Angiotensin 2 Receptor Blocker, Heterocyclic Compounds, 2-RingGliquidone
go.drugbank.com/drugs/DB01251ApprovedGliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. … This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesProducts: GLURENOR 30 MG TABLETTEN, Glurenorm 30 mg - Tabletten