Gliquidone

DB01251ApprovedSmall molecule

Gliquidone is a sulfonylurea drug used in the management of diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker.

Mechanism: The mechanism of action of gliquidone in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Gliquidone likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.
Curator reviewed
Primary indication: Used in the treatment of diabetes mellitus type 2.Curator reviewed · 1 structured indication
Formula / weight: C₂₇H₃₃N₃O₆S · 527.632 g/mol (avg)
Code names: ARDF-26

Resolves to

Compound

UNIIC7C2QDD75PCAS33342-05-1ChEMBLCHEMBL383634ChEBI93416PubChem91610KEGGD02430

Clinical / RWD

RxNorm25793ATCA10BB08PharmGKBPA164744895

Structure

InChIKeyLLJFMFZYVVLQKT-UHFFFAOYSA-NSMILESCOC1=CC2=C(C=C1)C(C)(C)C(=O)N(CCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1)C2=O

Targets

Q09428ABCC8Q15842KCNJ8P78508KCNJ10

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,044Drug interactionsStructured to mechanism, not free text

2Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

11ContraindicationsEach with its own population and attribute set

16Marketed productsAcross 5 countries and 6 labellers

1ATC codeIncluding every combination product, plus 11 drug categories

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Gliquidone, and which of those have an active Phase 3 trial?

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