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Pegvisomant
go.drugbank.com/drugs/DB00082ApprovedInvestigationalPegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. … Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: SOMAVERT® 15 MG POLVO LIOFILIZADO PARA SOLUCIÓN INYECTABLE, SOMAVERT 15 MG ENJEKSIYONLUK COZELTI ICIN TOZ ICEREN FLAKON VE COZUCU, 30 ADETMidostaurin
go.drugbank.com/drugs/DB06595ApprovedInvestigationalIt was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108]. … Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 InducersSynonyms: 4'-N-benzoylstaurosporineAbrocitinib
go.drugbank.com/drugs/DB14973ApprovedInvestigationalAbrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). … [L39774] The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of autoimmune and inflammatory diseases,
Categories: Heterocyclic Compounds, 1-Ring, Janus Kinase 1, antagonists & inhibitorsProducts: CIBINQO® 50 MG, CIBINQO® 200 MGFluticasone furoate
go.drugbank.com/drugs/DB08906ApprovedInvestigationalFluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications[FDA Label][F4364]. Fluticasone furoate was first approved in 2007[L5965].
Mixtures: RELVAR ELLIPTA 100/25 MCG KULLANIMA HAZIR INHALASYON TOZU ,3 X 30, RELVAR ELLIPTA 100/25 MCG KULLANIMA HAZIR INHALASYON TOZU ,14 DOZCategories: P-glycoprotein inducers, P-glycoprotein substratesEthionamide
go.drugbank.com/drugs/DB00609ApprovedInvestigationalWithdrawnA second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-ethyl-4-thiopyridylamide, 2-ethylthioisonicotinamideThalidomide
go.drugbank.com/drugs/DB01041ApprovedInvestigationalWithdrawnA piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. … It has been reintroduced and used for a number of inflammatory disorders and cancers.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesSynonyms: α-N-phthalylglutaramide, α-(N-phthalimido)glutarimidePenicillamine
go.drugbank.com/drugs/DB00859ApprovedInvestigationalPenicillamine is a pharmaceutical of the chelator class. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). … It is an α-amino acid metabolite of penicillin, although it has no antibiotic properties.
Categories: Compounds used in a research, industrial, or household settingSynonyms: D-β,β-dimethylcysteine, 3-mercapto-D-valineSulthiame
go.drugbank.com/drugs/DB08329ApprovedCategories: Heterocyclic Compounds, 1-RingProducts: Ospolot 50 mg Filmtabletten, Sultiam neuraxpharm 50 mg FilmtablettenMifepristone
go.drugbank.com/drugs/DB00834ApprovedInvestigationalMifepristone is a progestational and glucocorticoid hormone antagonist. … As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome.
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: MIFEPRISTONA 200 MG, MIFEPRISTONE 200 MGNilotinib
go.drugbank.com/drugs/DB04868ApprovedInvestigationalA Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to treatment with imatinib (Gleevec … Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML).
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: TASIGNA® 150 MG CAPSULAS, TASIGNA (200 MG)