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Displaying results 5491 - 5500 of 6949 in total
  1. Drug

    VPM1002

    go.drugbank.com/drugs/DB15801
    Investigational

    As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials. … The ability for mycobacterial antigens to reach the cytosol is due to this vaccine being engineered to secrete Hly which perforates phagosomal membranes.

  2. Drug

    Daledalin

    go.drugbank.com/drugs/DB09189
    Experimental

    It was in trials for depression in the 1970s but never marketed.

  3. Drug

    UC-781

    go.drugbank.com/drugs/DB05871
    Investigational

    UC-781 is a thiocarboxanilide non-nucleoside reverse transcriptase inhibitor (NNRTI). It is a topical microbicide targeted against the AIDS virus.

  4. Drug

    V1003

    go.drugbank.com/drugs/DB05046
    Experimental

    V1003 is an intranasal formulation of buprenorphine, an opiate analgesic, for the management of post-operative pain in hospital and home settings.

  5. Drug

    Esmirtazapine

    go.drugbank.com/drugs/DB06678
    Investigational

    Merck has terminated its internal clinical development program for esmirtazapine as of March 2010.

    Categories: Serotonin Receptor Antagonists, Adrenergic alpha-2 Receptor Antagonists
  6. Drug

    TBC-3711

    go.drugbank.com/drugs/DB05407
    Investigational

    TBC3711 is a next-generation endothelin antagonist that is being studied through oral and intravenous formulations by Encysive Pharmaceuticals.

    Categories: Endothelin Receptor Antagonists, Endothelin A Receptor Antagonists
  7. Drug

    COVID19 s-vax loaded autologous dendritic cell vaccine

    go.drugbank.com/drugs/DB15814
    Experimental

    DC-based vaccines are currently used in cancer therapeutics, and are being tested for COVID-19. … , and are able to present antigens through costimulatory signals required for activation of CD4+ and CD8+ T-cells.

  8. Drug

    Zastumotide

    go.drugbank.com/drugs/DB14926
    Investigational

    It is under investigation in clinical trial NCT00257738 (0804 GCC: MAGE-A3/HPV 16 Vaccine for Squamous Cell Carcinoma of the Head and Neck).

  9. Drug

    BB 21217

    go.drugbank.com/drugs/DB17373
    Investigational

    21217 is an anti-BCMA CAR T cell therapy that uses the same CAR molecule as [idecabtagene vicleucel] (bb2121), but adds the PI3K inhibitor bb007 during ex vivo culture to enrich the drug product (DP) for

  10. Drug

    RGX-501

    go.drugbank.com/drugs/DB17639
    Investigational

    It is being investigated for the treatment of homozygous familial hypercholesterolemia.[L46696] … RGX-501 is an adeno-associated virus vector 8 (AAV8)-mediated gene therapy that delivers a functional copy of the human low-density lipoprotein receptor (LDLR) gene to liver cells.