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Umeclidinium
go.drugbank.com/drugs/DB09076ApprovedInvestigationalUmeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath,...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesLoracarbef
go.drugbank.com/drugs/DB00447ApprovedWithdrawnLoracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid.
Selexipag
go.drugbank.com/drugs/DB11362ApprovedInvestigationalSelexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization. PAH is a relatively rare disease with usuall...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPlecanatide
go.drugbank.com/drugs/DB13170ApprovedInvestigationalPlecanatide is a drug approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation (CIC). It should not be used in children less than six years of age, and should be avoided in patients six years to 18 years o...
NKX101
go.drugbank.com/drugs/DB18131InvestigationalNKX101 is an investigational allogeneic chimeric antigen receptor (CAR)-natural killer cell therapy.
Synonyms: a fourth generation activating chimeric receptor (ACR) natural killer (NK) cell therapy engineered with an NKG2D ACR, OX40 costimulatory domain, CD3zeta signaling moiety, and membrane bound IL-15 (mb-IL15NS-3728
go.drugbank.com/drugs/DB05835ExperimentalNS3728 is an orally active chloride channel blocker for the treatment of cancer.
Vapitadine
go.drugbank.com/drugs/DB05738ExperimentalAn advantage of vapitadine over other antihistamines may be the absence of the sedation, even at high doses. … Vapitadine is an antihistamine that Barrier Therapeutics is developing as a treatment for allergic reactions of the skin, such as those associated with hives and for the itch associated with atopic dermatitis
Sonesitatug Vedotin
go.drugbank.com/drugs/DB18619InvestigationalCMG901 is an anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload.
Synonyms: an anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payloadZotarolimus
go.drugbank.com/drugs/DB18761InvestigationalZotarolimus is an immunosuppressant under investigation for use in drug-eluting stents.