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Cyclosporine
go.drugbank.com/drugs/DB00091ApprovedInvestigationalVet approved[A174049] Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118] … Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions.
Categories: BSEP/ABCB11 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: Cyclosporin A, Cyclosporine ALevosimendan
go.drugbank.com/drugs/DB00922ApprovedInvestigationalWithdrawnLevosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. … Levosimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).
Categories: Compounds used in a research, industrial, or household settingProducts: LEVOSIMENDAN EG, Levosimendan Carinopharm 12,5 mg Pulver für ein Konzentrat zur Herstellung einer InfusionslösungPrednisolone
go.drugbank.com/drugs/DB00860ApprovedInvestigationalVet approved[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431] … Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.
Synonyms: Predniso(lo)neInternational brands: Di-Adreson F, Di-Adreson-FColistimethate
go.drugbank.com/drugs/DB01111ApprovedInvestigationalVet approvedColistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms.
Products: COLISTIMETATO DE SODIO, COLISTIMETATO DE SODIO 2 MUIBenzocaine
go.drugbank.com/drugs/DB01086ApprovedInvestigational[A231219] It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.[A231259] … Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
Mixtures: E-Vac Plus, NORAVER P TABLETAS DE DISOLUCIÓN BUCALProducts: Ultracare Oral Anesthetic Creme de Menthe, Anesgerm LA MUELA Fast Pain ReliefAntihemophilic factor human
go.drugbank.com/drugs/DB13192ApprovedInvestigationalEndogenous Factor VIII is essential to the clotting process in the body due to its involvement in the clotting cascade where it is responsible for acting as a co-factor to Factor IX. … with conventional factor VIII due to conjugation to the dimeric Fc domain of human immunoglobulin G1, a long-lived plasma protein [A31551].
Mixtures: ENJEKSİYON/İNFÜZYON İÇİN TOZ VE ÇÖZÜCÜ, ENJEKSİYON/İNFÜZYON İÇİN TOZ VE ÇÖZÜCÜCategories: Hemophilia APotassium bicarbonate
go.drugbank.com/drugs/DB11098ApprovedInvestigationalPotassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. … [L1836] This FDA denomination classifies potassium bicarbonate as a GRAS ingredient.[L1837]
Products: Klor-con/ef, KLOR-Con/EFTazobactam
go.drugbank.com/drugs/DB01606ApprovedInvestigationalIt is combined with [Piperacillin] and [Ceftolozane] for the treatment of a variety of bacterial infections. … and mortality in hospitalized patients.
Mixtures: PIPERACILLINA E TAZOBACTAM MYLAN GENERICS, PIPERACILLINA E TAZOBACTAM MYLAN GENERICSProducts: TAZOCIN EFMagnesium
go.drugbank.com/drugs/DB14513ApprovedInvestigational[A19349] The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate. … [A32810] Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily
Mixtures: Supplements De Vitamines Et Mineraux, Calcium Et Magnesium Plus Vitamine D/fe/znProducts: EMGE 300MG PULV Z.HER E LO, MAGNEROT CLASSIC NAlfacalcidol
go.drugbank.com/drugs/DB01436ApprovedInvestigationalNutraceuticalAlfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of [vitamin D]. … The pharmacological actions of alfacalcidol are prolonged than vitamin D because a negative feedback mechanism regulates the final activation step of vitamin D in the kidneys.
Categories: Vitamin D and AnaloguesSynonyms: 1α-hydroxyvitamin D3, 1α-hydroxy-vitamin D3