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Milnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigationalMoreover, recent research has shown that the levorotatory enantiomer of milnacipran, levomilnacipran, may have the capacity to inhibit the activity of beta-site amyloid precursor protein cleaving enzyme … Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of treating fibromyalgia [F3925], although other regional regulatory authorities like the EMA, among others, have not
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeTedizolid phosphate
go.drugbank.com/drugs/DB09042Approved[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved [linezolid] and is generally effective against multidrug-resistant Gram-positive … [L11232, A199086, A199050] Tedizolid was approved by the FDA on June 20, 2014, for sale by Cubist Pharmaceuticals as tedizolid phosphate (SIVEXTRO®).
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeOspemifene
go.drugbank.com/drugs/DB04938ApprovedOspemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause
Categories: Sex Hormones and Modulators of the Genital SystemTechnetium Tc-99m oxidronate
go.drugbank.com/drugs/DB09139ApprovedWithdrawnThe group oxidronate falls into the category of diphosphonates whose structure allows them to bind to calcium. … [L1138] These complexes are formed by the binding of 99mTc to metal atoms of an organic molecule.
Synonyms: Technetium Tc 99m oxidronate, Technetium Tc-99m oxidronateSulfamethoxazole
go.drugbank.com/drugs/DB01015ApprovedInvestigationalin the biosynthesis of nucleic acids and proteins which are necessary for bacterial growth and division, and using them in conjunction helps to slow the development of bacterial resistance. … [L11830] In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial infections, including those of the urinary, respiratory, and gastrointestinal tracts.
Mixtures: TS-BAC, TS-BACAliskiren
go.drugbank.com/drugs/DB09026ApprovedInvestigationalAliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension. … [A203624] It was developed by Speedel and Novartis and initially approved by the FDA in early 2007.
Categories: Agents Acting on the Renin-Angiotensin SystemMepyramine
go.drugbank.com/drugs/DB06691ApprovedVet approvedIt has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions. … Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect.
Mixtures: Glen PE, Pyrichlor PEPeppermint oil
go.drugbank.com/drugs/DB11198ApprovedInvestigationalThe use of peppermint oil in the management of irritable bowel syndrome (IBS) has been investigated in many clinical studies due to its relaxing effects on smooth muscle; however the evidence supporting … , thereby facilitating its effect in the lower GI tract without effects in the upper tract [A33055].
Mixtures: The Natural Dentist Peppermint SageProducts: Esprit De Menthe PoivrefPork collagen
go.drugbank.com/drugs/DB14100ApprovedThe surgical implantation was first performed in Sweden. … The surgical implantation shows a tolerable safety profile and efficacy up to 4 years, but it is not indicated for patients with osteoarthritis.
Mixtures: Le-Blen Nano Collagen Peptide SerumBacillus calmette-guerin substrain russian BCG-I live antigen
go.drugbank.com/drugs/DB16648ApprovedInvestigational[L32734] It is to be marketed by Verity Pharmaceuticals, under the trade name VERITY-BCG, and manufactured by the Serum Institute of India. … It was developed to alleviate Canada's multi-year shortage of BCG vaccine, and is expected to be available by mid-2021.[L32734]