Mepyramine is an antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders. Mepyramine, or pyrilamine, targets the H1 receptor.
- Mechanism
- Curator reviewed
Mepyramine is a histamine H1 receptor inverse agonist. It binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Mepyramine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of Mepyramine occur at the subcortical level of the CNS.
- Primary indication
- Indicated for the treatment of allergic conditions, symptomatic relief of hypersensitivity reaction, and treatment of pruritic skin disorders.Curator reviewed · 9 structured indications
- Formula / weight
- C17H23N3O · 285.384 g/mol (avg)
- First approval
- Canada, 1997
- Also known as
- Pyranisamine · Pyrilamine
- Brand names
Resolves to
YECBIJXISLIIDS-UHFFFAOYSA-NSMILESCOC1=CC=C(CN(CCN(C)C)C2=NC=CC=C2)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Mepyramine, and which of those have an active Phase 3 trial?
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