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Esketamine
go.drugbank.com/drugs/DB11823ApprovedInvestigational[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. … Esketamine is the s-enantiomer of [Ketamine]. Ketamine is a mixture of two enantiomers (mirror image molecules). This is the first time that the FDA has approved esketamine for any use.
Synonyms: (S)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone, L-ketamineInternational brands: Keta-S, Ketanest SNimodipine
go.drugbank.com/drugs/DB00393ApprovedInvestigationalNimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. … By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl esterSodium ascorbate
go.drugbank.com/drugs/DB14482ApprovedInvestigationalNutraceuticalSynonyms: Vitamin C sodium, sodium L-ascorbateMixtures: VITAMINA C 500 MG. TABLETAS, VITAMINA C 500 MG TABLETASTrimetazidine
go.drugbank.com/drugs/DB09069ApprovedInvestigational[A233215] It is hypothesized that trimetazidine inhibits 3-ketoacyl coenzyme A thiolase, which decreases fatty acid oxidation but not glucose metabolism, preventing the acidic conditions that exacerbate … [L33015] Trimetazidine has been studied as a treatment for angina pectoris since the late 1960s.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-[2,3,4-trimethoxybenzyl] piperazine dihydrochlorideFondaparinux
go.drugbank.com/drugs/DB00569ApprovedInvestigationalOnce bound to heparin or HS, the anticoagulant activity of ATIII is potentiated by 1000-fold. Fondaparinux potentiates the neutralizing action of ATIII on activated Factor X 300-fold. … Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule.
Products: Arixtra Solution for Injection 5.0 mg/0.4 ml, ARIXTRA ® 7.5 MG /0.6 MLUrea
go.drugbank.com/drugs/DB03904ApprovedInvestigationalA compound formed in the liver from ammonia produced by the deamination of amino acids.
Mixtures: ÜRESAL FORTE %10 + %10 MERHEM (50 G), HYDROCORTISONE 1% ET UREA 5% CREAMProducts: UBIT TABLET 100 MG, Urea 50Tenoxicam
go.drugbank.com/drugs/DB00469ApprovedInvestigationalTenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesProducts: ZOLIMIN® INYECTABLE 20 MG., TİCOTEN 20 MG/2 ML I.M./I.V. ENJEKSİYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN LİYOFİLİZE TOZ VE ÇÖZÜCÜ, 1 ADETAtorvastatin
go.drugbank.com/drugs/DB01076ApprovedInvestigationalMore specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid. … [A181087, A181406] Some evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within five years) statin use leads to a 20%-22% relative reduction in
Mixtures: Trinomia 100 mg/20 mg/5 mg Hartkapseln, ATOPIR 20 MG/100 MG KAPSUL, 30 ADETCategories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesDanazol
go.drugbank.com/drugs/DB01406ApprovedInvestigationalA synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: CIPLADANOGEN® 200 MG CAPSULAS, DANASIN 50 MG KAPSUL, 100 ADETHepatitis A Vaccine
go.drugbank.com/drugs/DB10989ApprovedInvestigational[A199182] Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infection and safely confers strong protection … against the disease caused by infection with this virus.
Synonyms: Hepatitis A Vaccine, Hepatitis A vaccine, inactivatedSalts: Hepatitis A virus strain CR 326F antigen (formaldehyde inactivated), Hepatitis A virus strain HM175 antigen (formaldehyde inactivated)