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Filorexant
go.drugbank.com/drugs/DB12158InvestigationalFilorexant has been used in trials studying the prevention and treatment of Migraine, Headache, Polysomnography, Diabetic Neuropathy, Painful, and Major Depressive Disorder, Recurrent.
Categories: Heterocyclic Compounds, 1-RingDupilumab
go.drugbank.com/drugs/DB12159ApprovedInvestigationalDupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. … [L7186] Dupilumab is commonly marketed as Dupixent, which is available as a formulation for subcutaneous injection. It was first approved by the FDA in 2017.
Categories: Interleukin-4 Receptor alpha Antagonist, Interleukin 4 Receptor alpha AntagonistsProducts: DUPIXENT® 300MG, DUPIXENT® 200MGDeutetrabenazine
go.drugbank.com/drugs/DB12161ApprovedInvestigationalIt is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated [DB04844] [A32046]. … Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesNimorazole
go.drugbank.com/drugs/DB12172InvestigationalNimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others.
Categories: Heterocyclic Compounds, 1-RingApitolisib
go.drugbank.com/drugs/DB12180InvestigationalApitolisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Prostate Cancer, Renal Cell Carcinoma, and Endometrial Carcinoma, among others.
Categories: Heterocyclic Compounds, 1-Ring, Phosphatidylinositol 3-Kinases, antagonists & inhibitorsAbacavir hydroxyacetate
go.drugbank.com/drugs/DB12187InvestigationalPrurisol is under investigation for the treatment of Chronic Stable Plaque Psoriasis. Prurisol has been investigated for the treatment of Plaque Psoriasis.
Categories: Heterocyclic Compounds, 2-RingEtrolizumab
go.drugbank.com/drugs/DB12189InvestigationalInflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is typified by a chronic gastrointestinal inflammatory microenvironment, driven in part by the excessive infiltration … [A244564, A244569, A244579, A244584] A recent class of drugs designed to impair lymphocyte homing, so-called "anti-trafficking agents" (ATAs), have shown some success and include approved drugs such as
Lenabasum
go.drugbank.com/drugs/DB12193InvestigationalAjulemic acid has been used in trials studying the treatment of Cystic Fibrosis, Dermatomyositis, and Diffuse Cutaneous Systemic Sclerosis.
Synonyms: (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene-9-carboxylic acidCategories: Interleukin-1, antagonists & inhibitorsVP-14637
go.drugbank.com/drugs/DB12195InvestigationalMDT-637 has been investigated for the treatment of Drug Safety.
Categories: Heterocyclic Compounds, 1-RingTivantinib
go.drugbank.com/drugs/DB12200InvestigationalTivantinib has been investigated in Solid Tumors.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring