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Binimetinib
go.drugbank.com/drugs/DB11967ApprovedInvestigationalBinimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: MEKTOVI® 15 MG TABLETAS RECUBIERTASPonesimod
go.drugbank.com/drugs/DB12016ApprovedInvestigational[A232079,L32709] Ponesimod was developed out of a need for a more selective modulator of sphingosine 1-phosphate receptor 1 than [fingolimod]. … Ponesimod is a selective sphingosine 1-phosphate receptor 1 modulator indicated in the treatment of relapsing forms of multiple sclerosis in adults.
Categories: Sphingosine 1-phosphate Receptor Modulator, Sphingosine 1 Phosphate Receptor ModulatorsBenralizumab
go.drugbank.com/drugs/DB12023ApprovedInvestigationalBenralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils … [A31294] It inhibits the binding of IL-5 as well as the hetero-oligomerization of the alpha and beta subunits of the IL-5R, thus blocking signal transduction.
Categories: Interleukin-5 Receptor alpha-directed Cytolytic Antibody, Interleukin 5 Receptor alpha-directed Antibody InteractionsProducts: FASENRA®Ritobegron
go.drugbank.com/drugs/DB12080InvestigationalRitobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin in Healthy Male and Female Volunteers).
Categories: Adrenergic beta-3 Receptor AgonistsEstetrol
go.drugbank.com/drugs/DB12235ApprovedInvestigationalThe combination of drospirenone and estetrol offers a new choice with a favourable safety profile for women seeking contraceptive therapy. … [L33184] Estetrol (E4) is a native estrogen occurring naturally during pregnancy, but can be synthesized from a plant source and used for contraception.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFexinidazole
go.drugbank.com/drugs/DB12265ApprovedHuman African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by _T. brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per … Transmitted by the bite of an infected tsetse fly, HAT is biphasic with a first (hemolymphatic) stage that progresses to a second (meningoencephalitic) stage in which patients experience progressively
Categories: MATE 2-K Inhibitors, MATE 1 InhibitorsAducanumab
go.drugbank.com/drugs/DB12274ApprovedInvestigationalin amyloid-β plaques. … Aducanumab, or BIIB037, is a monoclonal IgG1 antibody that targets extracellular amyloid-β plaques in the brain; similar to [gantenerumab], [bapineuzumab] and [solanezumab].
Polihexanide
go.drugbank.com/drugs/DB12277ApprovedInvestigational[A1351] It is effective against a wide range of Gram-positive and Gram-negative bacteria. … Polihexanide, also known as polyhexamethylene biguanide (PHMB), is a broad-spectrum antimicrobial polymer primarily used for topical antisepsis and wound management.
Mixtures: Ucheer CCategories: Compounds used in a research, industrial, or household settingRadotinib
go.drugbank.com/drugs/DB12323InvestigationalRadotinib is under investigation for the treatment of Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
Categories: Heterocyclic Compounds, 1-RingRicolinostat
go.drugbank.com/drugs/DB12376InvestigationalRicolinostat is under investigation for the treatment of Breast Carcinoma and Metastatic Breast Cancer.
Categories: Heterocyclic Compounds, 1-Ring