Estetrol is an estrogen used in combination with drospirenone for oral contraception. Naturally or synthetically produced steroid estrogens have a wide range of pharmaceutical uses ranging from hormonal contraception to the treatment of menopausal symptoms.
- Mechanism
- Curator reviewed · 4 references
Estetrol is a synthetic analogue of a naturally occurring estrogen present during pregnancy, demonstrating selectivity for both estrogen receptor-α (ER-α) and ER-β and suppressing ovulation. Estetrol binds with a low to moderate affinity human estrogen receptor alpha (ER alpha) and ER beta with a preference for ER alpha. Estetrol demonstrates a unique mechanism of action via tissue selective activity, showing estrogen receptor agonist activity on the vagina, the uterus and the endometrium, and negative estrogenic activity on breast tissue.
- Primary indication
- Estetrol is indicated in combination with drospirenone for the prevention of pregnancy.Curator reviewed · 1 structured indication
- Formula / weight
- C18H24O4 · 304.3808 g/mol (avg)
- First approval
- Canada, 2021 · United States, 2021 · European Union, 2021
- Also known as
- Oestetrol
- Brand names
Resolves to
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Which drugs share a target with Estetrol, and which of those have an active Phase 3 trial?
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