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MLN3897
go.drugbank.com/drugs/DB06505ExperimentalMLN3897, a novel CCR1 inhibitor, disrupts osteoclast formation and blocks the interaction between multiple myeloma cells and osteoclasts.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: (4S)-4-(4-CHLOROPHENYL)-1-((3E)-3-(9-(1-HYDROXY-1-METHYL-ETHYL)-5H-(1)BENZOXEPINO(3,4-B)PYRIDIN-11-YLIDENE)PROPYL)-3,3-DIMETHYL-PIPERIDIN-4-OL, BENZOXEPINO(3,4-B)PYRIDINE-7-METHANOL, 5-(3-((4S)-4-(4-CHLOROPHENYL)-4-HYDROXY-3,3-DIMETHYL-1-PIPERIDINYL)PROPYLIDENE)-5,11-DIHYDRO-.ALPHA.,.ALPHA.-DIMETHYL-Ganulameran
go.drugbank.com/drugs/DB16442InvestigationalAs such, BNT162b3 has entered a phase I/II study in early September 2020 (NCT04537949). … The BNT162b3 vaccine is the latest addition to BioNTech and partner Pfizer’s mRNA COVID-19 vaccine program. Similar to [BNT162b2], BNT162b3 uses a nucleoside-modified RNA (modRNA) technology.
Phenindamine
go.drugbank.com/drugs/DB01619ApprovedPhenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. … Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and
Categories: Heterocyclic Compounds, 1-RingAV-COVID-19
go.drugbank.com/drugs/DB15802InvestigationalAV-COVID-19 is a vaccine composed of autologous dendritic cells loaded with SARS-CoV-2 antigens and with or without Granulocyte-macrophage colony-stimulating factor (GM-CSF). … As of July 2020, the company is pursuing an adaptive Phase IB-II Randomized Clinical Trial (NCT04386252) to test the vaccine.
Acellular nerve allograft
go.drugbank.com/drugs/DB30293ApprovedInvestigationalOur team is working on the full update, which will be available soon. [L54673,L54668] … Approved by the FDA under a Biologics License Application (BLA) as an acellular nerve scaffold for the treatment of adult and pediatric patients (aged ≥1 month) with sensory, mixed, and motor peripheral
Detomidine
go.drugbank.com/drugs/DB11556InvestigationalVet approvedDetomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. … This drug is prescribed by veterinarians and is marketed as _Dormosedan_. Currently, it is only approved by the FDA for use in horses but has been studied for use in other large animals.
Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-2 Receptor AgonistsSynonyms: 4-(2,3-dimethylbenzyl)imidazoleChlorambucil
go.drugbank.com/drugs/DB00291ApprovedInvestigationalAlthough it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed) … A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases.
Synonyms: N,N-di-2-chloroethyl-γ-p-aminophenylbutyric acid, γ-[p-di(2-chloroethyl)aminophenyl]butyric acidProducts: ลูเคอแรน (เม็ด 2 มก.), Leukeran 2 mg - FilmtablettenCidofovir
go.drugbank.com/drugs/DB00369ApprovedInvestigationalCidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS.
Categories: Heterocyclic Compounds, 1-RingSynonyms: (S)-HPMPC, (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosineDexfenfluramine
go.drugbank.com/drugs/DB01191ApprovedIllicitWithdrawnDexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. … For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: (S)-fenfluramine, (S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine