Chlorambucil is a chemotherapy agent used in the management of chronic lymphocytic leukemia and malignant lymphomas. A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases.
- Mechanism
- Curator reviewed
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
- Primary indication
- For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia.Curator reviewed · 11 structured indications
- Formula / weight
- C14H19Cl2NO2 · 304.212 g/mol (avg)
- First approval
- Canada, 2017 · United States, 1985
- Also known as
- Ambochlorin · Chloraminophen
- Code names
- CB-1348 · NCI-3088 · NSC-3088
- Brand names
Resolves to
JCKYGMPEJWAADB-UHFFFAOYSA-NSMILESOC(=O)CCCC1=CC=C(C=C1)N(CCCl)CCClWhat you can answer from here — as of September 23, 2026
Which other approved drugs treat the same conditions as Chlorambucil, and which companies have late-stage candidates in those indications?
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