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Displaying results 581 - 590 of 10000 in total
  1. Drug

    Omacetaxine mepesuccinate

    go.drugbank.com/drugs/DB04865
    ApprovedInvestigationalWithdrawn

    Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies … Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML.

    Synonyms: CEPHALOTAXINE 4-METHYL (2R)-2-HYDROXY-2-(4-HYDROXY-4-METHYLPENTYL)BUTANEDIOATE (ESTER), CEPHALOTAXINE, 4-METHYL (2R)-2-HYDROXY-2-(4-HYDROXY-4-METHYLPENTYL)BUTANEDIOATE (ESTER)Categories: Heterocyclic Compounds with 4 or More Rings, Heterocyclic Compounds, 2-Ring
  2. Drug

    Enavogliflozin

    go.drugbank.com/drugs/DB18970
    Investigational

    Enavogliflozin is under investigation in clinical trial NCT06399835 (Enavogliflozin vs. Pioglitazone on Glucose and Atherosclerosis).

    Synonyms: (1s)-1,5-anhydro-1-c-(7-chloro-6-((4-cyclopropylphenyl)methyl)-2,3-dihydro-4-benzofuranyl)-d-glucitol, D-glucitol, 1,5-anhydro-1-c-(7-chloro-6-((4-cyclopropylphenyl)methyl)-2,3-dihydro-4-benzofuranyl)-, (1s)-Categories: Drugs Used in Diabetes, Cytochrome P-450 Substrates
  3. Drug

    4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL

    go.drugbank.com/drugs/DB07336
    Experimental

    Synonyms: 4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL
  4. Drug

    Methylthioinosine

    go.drugbank.com/drugs/DB02896
    Experimental

    An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position.

    Synonyms: 6-methyl MP riboside, 6-methyl MP-ribosideCategories: Heterocyclic Compounds, 2-Ring
  5. Drug

    Zardaverine

    go.drugbank.com/drugs/DB02918
    Experimental

    Synonyms: 6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinoneCategories: Heterocyclic Compounds, 1-Ring
  6. Drug

    Sildenafil

    go.drugbank.com/drugs/DB00203
    ApprovedInvestigational

    Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in … In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850

    Synonyms: 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazineMixtures: DAPOKSEL 30 MG/50 MG FILM TABLET ,6 FILM TABLET, DAPOXIL 30/50 MG FILM KAPLI TABLET, 6 FILM KAPLI TABLET
  7. Drug

    [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile

    go.drugbank.com/drugs/DB07168
    Experimental

    Synonyms: [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
  8. Drug

    N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine

    go.drugbank.com/drugs/DB07249
    Experimental

    Synonyms: N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine
  9. Drug

    Dexmedetomidine

    go.drugbank.com/drugs/DB00633
    ApprovedInvestigationalVet approved

    An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

    Synonyms: (+)-4-((S)-α,2,3-trimethylbenzyl)imidazole, (+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazoleCategories: Cytochrome P-450 Substrates, Adrenergic alpha-2 Receptor Agonists
  10. Drug

    Acoramidis

    go.drugbank.com/drugs/DB17999
    ApprovedInvestigational

    Acoramidis is a small molecule stabilizer of transthyretin (TTR) for use in patients with TTR amyloidosis. … [A264768] Although they share a mechanism of action, acoramidis is more selective for TTR and is a more potent stabilizer when compared to tafamidis.

    Synonyms: 3-(3-(3,5-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acidCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 Inhibitors