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Displaying results 581 - 590 of 10000 in total
  1. Drug

    Bortezomib

    go.drugbank.com/drugs/DB00188
    ApprovedInvestigational

    Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. … [A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide, [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid
  2. Drug

    Zinc;[amino-[2-[[5-[amino(azaniumylidene)methyl]benzimidazol-1-id-2-yl]methyl]benzimidazol-1-id-5-yl]methylidene]azanium

    go.drugbank.com/drugs/DB04008
    Experimental

    Synonyms: Zinc;[amino-[2-[[5-[amino(azaniumylidene)methyl]benzimidazol-1-id-2-yl]methyl]benzimidazol-1-id-5-yl]methylidene]azanium, bis(5-amidino-benzimidazolyl)methane zinc
  3. Drug

    Olaparib

    go.drugbank.com/drugs/DB09074
    ApprovedInvestigational

    [L41100, L40908, L43792] It was first approved by the FDA and EU in December 2014,[A246020] and by Health Canada in April 2016.[L42820] … [L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell

    Categories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-RingSynonyms: 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one
  4. Drug

    Penciclovir

    go.drugbank.com/drugs/DB00299
    Approved

    Displaying low toxicity and good selectivity, penciclovir is a nucleoside analogue. … Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingSynonyms: 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine, 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine
  5. Drug

    Eliglustat

    go.drugbank.com/drugs/DB09039
    ApprovedInvestigational

    Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease. … [A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide.

    Synonyms: N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1-pyrrolidinyl)-2-propanyl]octanamideCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitors
  6. Drug

    Bedaquiline

    go.drugbank.com/drugs/DB08903
    ApprovedInvestigational

    Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. … [A261866] Although it is closely related to fluoroquinolones, bedaquiline does not affect DNA gyrase; instead, bedaquiline inhibits the c subunit of ATP synthase responsible for synthesizing ATP.

    Synonyms: 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-olCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  7. Drug

    Doxifluridine

    go.drugbank.com/drugs/DB12947
    Investigational

    Doxifluridine has been investigated for the treatment of Stomach Cancer.

    Synonyms: 1-(β-D-5-desoxyribofuranoxyl)-5-fluoruracil, 5-fluoro-5'-deoxyuridineCategories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Entacapone

    go.drugbank.com/drugs/DB00494
    ApprovedInvestigational

    Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. … of levodopa and a decarboxylase inhibitor.

    Mixtures: LEVO/CA/EN 50/12.5/200 STD, LEVO/CA/EN 50/12.5/200 STDCategories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
  9. Drug

    Zoxazolamine

    go.drugbank.com/drugs/DB19372
    ApprovedWithdrawn

    Synonyms: 2-amino-5-chlorobenzoxazole, 5-chloro-2-benzoxazolamineCategories: Heterocyclic Compounds, 2-Ring
  10. Drug

    Mexiletine

    go.drugbank.com/drugs/DB00379
    ApprovedInvestigational

    It may have some anticonvulsant properties.

    Categories: Antiarrhythmics, Class I, Cytochrome P-450 SubstratesSynonyms: 1-(2',6'-dimethylphenoxy)-2-aminopropane, (±)-1-(2,6-dimethylphenoxy)propan-2-amine