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Displaying results 581 - 590 of 10000 in total
  1. Drug

    Dordaviprone

    go.drugbank.com/drugs/DB14844
    ApprovedInvestigational

    Factor 4 (ATF4), and induction of endoplasmic reticulum (ER) stress response. … [L53838] It is used to treat patients with diffuse midline glioma harboring an H3 K27M mutation.

    Categories: MATE 1 Inhibitors, MATE 2 InhibitorsSynonyms: 2,4,6,7,8,9-Hexahydro-4-((2-methylphenyl)methyl)-7-phenylmethyl)imidazo)(1,2-a)pyrido(3,4-e)pyrimidin-5(1H)-one, 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo(1,2-A)pyrido(3,4-E)pyrimidin-5(4H)-one
  2. Drug

    Ticagrelor

    go.drugbank.com/drugs/DB08816
    ApprovedInvestigational

    [A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug. … Ticagrelor was granted EMA approval on 3 December 2010.[L14207] Ticagrelor was granted FDA approval on 20 July 2011.[L14201]

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
  3. Drug

    Levetiracetam

    go.drugbank.com/drugs/DB01202
    ApprovedInvestigational

    make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions. … Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders.

    Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingProducts: Ran-levetiracetam, Van-levetiracetam
  4. Drug

    Mertiatide

    go.drugbank.com/drugs/DB15780
    Investigational

    Products: NEPHROMAG EQUIPOS DE REACTIVOS PARA PREPARACION RADIOFARMACEUTICA.
  5. Drug

    Latanoprost

    go.drugbank.com/drugs/DB00654
    ApprovedInvestigational

    Another benefit latanoprost is that it can be administered once a day.[A184490] … Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998.

    Mixtures: Tim-Dor-Lat, Tim-Brim-Dor-LatCategories: Prostaglandins F, Synthetic, Compounds used in a research, industrial, or household setting
  6. Drug

    Bendamustine

    go.drugbank.com/drugs/DB06769
    ApprovedInvestigational

    Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. … Bendamustine is a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL).

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: BENDAMUSTINA DR. REDDY'S, BEN SPAL-P® 25
  7. Drug

    Potassium

    go.drugbank.com/drugs/DB14500
    ApprovedInvestigational

    Hypokalemia (low potassium) or hyperkalemia (high potassium) may result, manifesting as various signs and symptoms. … Potassium is an essential nutrient, like [Calcium] and [Magnesium]. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans.

    Mixtures: Cal & Mag Hvp Chel Plus C Potass & Zinc Tab, C. Vit-min FormulaSynonyms: K
  8. Target

    Cation-independent mannose-6-phosphate receptor

    go.drugbank.com/bio_entities/BE0003623
    TargetTransporterHumans

    Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phos...

    Synonyms: CI Man-6-P receptor
  9. Drug

    Secnidazole

    go.drugbank.com/drugs/DB12834
    ApprovedInvestigational

    Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria as well as protozoa. … [A245503] Secnidazole has been available in many other countries in Europe, Asia, South America, and Africa for decades.

    Mixtures: KADMIZOL®-F, GYNFLU® D TABLETASCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
  10. Drug

    Trolamine salicylate

    go.drugbank.com/drugs/DB11079
    Approved

    Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. … As with other salicylates, trolamine salicylate is an inhibitor of cyclo-oxygenase (COX) enzymes with no reported selectivity towards a specific enzyme isoform.

    Categories: Non COX-2 selective NSAIDSProducts: Dr Joe lab ARTHRITIS EXTRA STRENGTH, Ultracin T