Trolamine salicylate is a medication used to relieve minor aches and pains of the muscles and joints. Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid.
- Mechanism
- Curator reviewed · 3 references
Inflammation and tissue damage in different conditions including arthritis, bursitis, joint disorder, bruises, and strains or sprains of muscle origin, induce mild to moderate pain and are associated with increase prostaglandin synthesis. This is thought to be a result of COX-2 enzyme induction. COX-2 is induced in inflammatory cells in case of cell injury, infection or activation from inflammatory cytokines such as interleukin (IL)-1 and tumor necrosis factor (TNF)-α. Upon activation, COX-2 produces prostanoid mediators of inflammation such as prostaglandins and thromboxanes. Trolamine salicylate mediates its analgesic effect by inhibiting the production of inflammatory mediators that sensitize nociceptive nerve endings and generate pain.
- Primary indication
- Indicated for the temporary relief of aches, and pains of muscles and joints associated with backache, lumbago, strains, bruises, sprains and arthritic or rheumatic pain, pain of tendons and ligaments.Curator reviewed
- Formula / weight
- C13H21NO6 · 287.312 g/mol (avg)
- First approval
- Canada, 1999 · United States, 2019
- Brand names
Resolves to
UEVAMYPIMMOEFW-UHFFFAOYSA-NSMILESOCCN(CCO)CCO.OC(=O)C1=CC=CC=C1OWhat you can answer from here — as of May 03, 2025
Which drugs share a target with Trolamine salicylate, and which of those have an active Phase 3 trial?
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