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Displaying results 51 - 60 of 1059 in total
  1. Drug

    Nogapendekin alfa

    go.drugbank.com/drugs/DB18740
    ApprovedInvestigational

    Nogapendekin alfa is a human IL-15N72D variant. It is one of the active ingredients in Anktiva, a combination product also containing inbakicept, where a single inbakicept is complexed with two nogapendekin alfa components. This combinat...

    Synonyms: Superagonist interleukin-15:interleukin-15 receptor alphasu/fc fusion complex alt-803Categories: Interleukin-15 Receptor Agonist
  2. Drug

    Goflikicept

    go.drugbank.com/drugs/DB16396
    Investigational

    Goflikicept is under investigation in clinical trial NCT04380519 (Study of the Efficacy and Safety of a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe Acute Respiratory Syndrome Coron...

    Synonyms: Heterodimeric fusion protein that binds to IL-1 beta consisting of human extracellular domain of IL1 receptor and a mutant Fc fragment of human IGg1 and part of human IL1 receptor accessory protein
  3. Drug

    Nelipepimut-S

    go.drugbank.com/drugs/DB06226
    Investigational

    Synonyms: Human receptor tyrosine-protein kinase erbB-2 (proto-oncogene Neu, tyrosine kinase-type cell surface receptor HER2, CD340)-(347-355)-peptideCategories: Receptor Protein-Tyrosine Kinases, Receptor, Epidermal Growth Factor
  4. Drug

    Trastuzumab duocarmazine

    go.drugbank.com/drugs/DB16342
    Investigational

    Trastuzumab duocarmazine is under investigation in clinical trial NCT03262935 (SYD985 vs. Physician's Choice in Participants With Her2-positive Locally Advanced or Metastatic Breast Cancer).

    Synonyms: Immunoglobulin g1-kappa, anti-(homo sapiens erbb2 (epidermal growth factor receptor 2, receptor tyrosineprotein kinase erbb-2, egfr2, her2, her-2, p185cerbb2, neu, cd340)), humanized monoclonal antibodyCategories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
  5. Drug

    TOL-101

    go.drugbank.com/drugs/DB16980
    Investigational

    Synonyms: Murine IgM monoclonal antibody specific for the human alpha, beta T cell receptor
  6. Drug

    Becotatug

    go.drugbank.com/drugs/DB19069
    Investigational

    JMT101 in Combination With Osimertinib, Versus Cisplatin-pemetrexed in Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Characterized by Epithermal Growth Factor Receptor

    Synonyms: Jmt101 (fully human monoclonal igg1 antibody targeting epidermal growth factor receptor (egfr)), Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-Mus musculus monoclonal JMT101 γ1-chain), disulfide with human-Mus musculus monoclonal JMT101 κ-chain, dimer
  7. Drug

    EDI-200

    go.drugbank.com/drugs/DB18188
    Investigational

    EDI-200 is a fusion protein consisting of human immunoglobim G1 constant region Fc region fused to the human receptor binding domain of ectodysplasin-A1.

    Synonyms: HUMAN IMMUNOGLOBULIN G1 CONSTANT REGION - HUMAN ECTODYSPLASIN-A1 RECEPTOR-BINDING DOMAIN FUSION PROTEIN
  8. Drug

    PBCAR20A

    go.drugbank.com/drugs/DB17189
    Investigational

    Synonyms: Allogeneic gene edited CD20-directed CAR (Chimeric Antigen Receptor) T cells
  9. Pathway

    Sphingolipid Signaling (Receptor)

    smpdb.ca/view/SMP0524344
    Signaling

    Through these receptor‑specific G protein couplings—spanning cAMP suppression, Ca²⁺ mobilization, PKC activation, Rho GTPase–driven cytoskeletal remodeling, and PI3K/Akt and MAPK pathways—S1P orchestrates

    Drugs: Nitric oxide · Calcium · Magnesium cation
    Enzymes: Sphingosine 1-phosphate receptor 2, Sphingosine 1-phosphate receptor 4
  10. Drug

    Recombinant human alkaline phosphatase

    go.drugbank.com/drugs/DB17672
    Investigational

    Synonyms: recAP