Nitric Oxide is a vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates. Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO.
- Mechanism
- Curator reviewed
Nitric oxide is a compound produced by many cells of the body. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation.
- Primary indication
- For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failureCurator reviewed · 1 structured indication
- Formula / weight
- NO · 30.0061 g/mol (avg)
- First approval
- Canada, 2005 · United States, 1999 · European Union, 2016
- Also known as
- EDRF · endothelium-derived relaxing factor · Mononitrogen monoxide · Nitrogen monooxide · Nitrogen monoxide
- Code names
- OHM-11771
- Brand names
Resolves to
MWUXSHHQAYIFBG-UHFFFAOYSA-NSMILES[N]=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Nitric Oxide, and which of those have an active Phase 3 trial?
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