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Displaying results 51 - 60 of 10000 in total
  1. Drug

    Topotecan

    go.drugbank.com/drugs/DB01030
    ApprovedInvestigational

    An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.

    Synonyms: 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecinCategories: MATE 2 Substrates, MATE 2 Substrates with a Narrow Therapeutic Index
  2. Drug

    Methotrexate

    go.drugbank.com/drugs/DB00563
    ApprovedInvestigational

    [A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division. … [L7180] Methotrexate was granted FDA approval on 7 December 1953.[L7198]

    Synonyms: 4-amino-10-methylfolic acid, 4-amino-N(10)-methylpteroylglutamic acidCategories: Heterocyclic Compounds, 2-Ring
  3. Drug

    Moricizine

    go.drugbank.com/drugs/DB00680
    ApprovedWithdrawn

    An antiarrhythmia agent used primarily for ventricular rhythm disturbances.

    Synonyms: [10-(3-Morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl ester, ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamateCategories: Heterocyclic Compounds, 1-Ring
  4. Drug

    Thioproperazine

    go.drugbank.com/drugs/DB01622
    Approved

    It is virtually without antiserotonin and hypotensive action and has no antihistaminic property. … Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects.

    Categories: Adrenergic alpha-1 Receptor AntagonistsSynonyms: 2-dimethylsulfamido-(10-(3-1-methylpiperazinyl-4)propyl)-phenothiazine, N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine-2-sulfonamide
  5. Drug

    Estradiol

    go.drugbank.com/drugs/DB00783
    ApprovedInvestigationalVet approved

    [L11485,L11488,L11491, L11494,L11497,L11500,L11503] When used for oral or IM administration, estradiol is commonly synthesized as a pro-drug ester (such as [DB13952], [DB13953], [DB13954], [DB13955 … Because it has a low oral bioavailability on its own, estradiol is commonly formulated with an ester side-chain.

    Synonyms: (17β)-estra-1,3,5(10)-triene-3,17-diol, 17β-estra-1,3,5(10)-triene-3,17-diolInternational brands: Estraderm MX
  6. Drug

    Thioridazine

    go.drugbank.com/drugs/DB00679
    ApprovedWithdrawn

    It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. … Thioridazine was withdrawn worldwide in 2005 due to its association with cardiac arrythmias.

    Synonyms: 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine, 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazineCategories: Adrenergic alpha-1 Receptor Antagonists
  7. Drug

    Perphenazine

    go.drugbank.com/drugs/DB00850
    ApprovedInvestigational

    An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.

    Synonyms: 2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol, 2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazineMixtures: Etrafon 2 10, โพลีบอน 4-10
  8. Drug

    10-decarboxymethylaclacinomycin A

    go.drugbank.com/drugs/DB01806
    Experimental

    Synonyms: 10-decarboxymethylaclacinomycin A
  9. Drug

    ADL 10-0101

    go.drugbank.com/drugs/DB05443
    Experimental

    ADL 10-0101 is a peripheral kappa opioid agonist analgesic product candidate. … Preclinical trials of ADL 10-0101 have suggested that the compound may be effective for the treatment of inflammatory pain, itch and visceral pain.

  10. Drug

    Naloxegol

    go.drugbank.com/drugs/DB09049
    ApprovedInvestigational

    It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain.

    Synonyms: (5α,6α)-17-Allyl-6-[(20-hydroxy-3,6,9,12,15,18-hexaoxaicos-1-yl)oxy]-4,5-epoxymorphinan-3,14-diol