Thioridazine is a phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior.
- Mechanism
- Curator reviewed
Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
- Primary indication
- For the treatment of schizophrenia and generalized anxiety disorder.Curator reviewed · 2 structured indications
- Formula / weight
- C21H26N2S2 · 370.575 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1983
- Also known as
- Thioridazin
- Code names
- TP-21
Resolves to
KLBQZWRITKRQQV-UHFFFAOYSA-NSMILESCSC1=CC2=C(SC3=CC=CC=C3N2CCC2CCCCN2C)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Thioridazine, and which of those have an active Phase 3 trial?
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