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Thymidine
go.drugbank.com/drugs/DB04485ApprovedInvestigationaltoxicity of established anti-metabolite chemotherapeutic agents, such as 5-Fluorouracil (FU), Methotrexate (MTX), and Cytosine arabinoside (ara-C). … Thymidine is a naturally occurring deoxyribonucleoside that is a crucial component of the DNA salvage pathway and a building block for DNA synthesis.
Categories: Heterocyclic Compounds, 1-RingSynonyms: MT-1621 COMPONENT 2'-DEOXYTHYMIDINE, 1-(2-Deoxy-?-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedioneZolmitriptan
go.drugbank.com/drugs/DB00315ApprovedInvestigationalZolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)<sub>1B/1D/(1F)</sub> receptor agonists used to treat acute migraine. … [A193797] Zolmitriptan was first approved by the FDA for sale by Zeneca Pharmaceuticals under the trade name Zomig® on November 25, 1997.
Categories: Heterocyclic Compounds, 2-Ring, Serotonin 5-HT1 Receptor AgonistsSynonyms: 4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one, (S)-4-({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-oneMethylchloroisothiazolinone
go.drugbank.com/drugs/DB14197ApprovedSensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test. … Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingSynonyms: 5-Chloro-2-methyl-3(2H)-isothiazolone, 4-Isothiazolin-3-one, 5-chloro-2-methyl-Lumiracoxib
go.drugbank.com/drugs/DB01283ApprovedWithdrawnLumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). … On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver
Categories: COX-2 Inhibitors, Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Synonyms: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acidOlmesartan
go.drugbank.com/drugs/DB00275ApprovedInvestigationalOlmesartan is commonly used for the management of hypertension and Type 2 Diabetes-associated nephropathy, particularly in patients who are unable to tolerate ACE inhibitors. … [A174124,A178153,A173869,A185324,A185327,A185333,A185342,A185345] Like other ARBs, olmesartan blockade of RAAS slows the progression of diabetic nephropathy due to its renoprotective effects.
Mixtures: OLMEPRESS D, OLMEDIPIN ® D 20/12.5 TABLETA RECUBIERTACategories: Angiotensin 2 Receptor BlockerLevomenthol
go.drugbank.com/drugs/DB00825ApprovedInvestigationalMenthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. … Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration
Mixtures: KAMFOLIN 150 MG/G+100 MG/G MERHEM, 50 G, Benylin DM-D-E With MenthactinCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesLatanoprost
go.drugbank.com/drugs/DB00654ApprovedInvestigationalAnother benefit latanoprost is that it can be administered once a day.[A184490] … Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998.
Mixtures: Akistan Duo 50 Mikrogramm/ml + 5 mg/ml Augentropfen, Lösung, Xalacom 50 Mikrogramm/ml + 5 mg/ml AugentropfenCategories: Prostaglandins F, Synthetic, Compounds used in a research, industrial, or household settingTamsulosin
go.drugbank.com/drugs/DB00706ApprovedInvestigationalTamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common. … [Label] Other alpha-1 adrenoceptor antagonists developed in the 1980s were less selective and more likely to act on the smooth muscle of blood vessels, resulting in hypotension.
Synonyms: (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide, (R)-(−)-tamsulosinInternational brands: Harnal DPerampanel
go.drugbank.com/drugs/DB08883ApprovedInvestigationalPerampanel is a noncompetitive AMPA glutamate receptor antagonist. … It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersSynonyms: 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-oneRosiglitazone
go.drugbank.com/drugs/DB00412ApprovedInvestigationalRecent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. … This is the subject of a clinical trial currently underway.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersSynonyms: (±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedione, (RS)-5-{4-[2-(Methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedion