Levomenthol is an organic compound used to treat mild to moderate muscle and joint pain. Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.
- Mechanism
- Curator reviewed
Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin. Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptor agonism.
- Primary indication
- Used to treat occasional minor irritation, pain, sore mouth, and sore throat as well as cough associated with a cold or inhaled irritants.Curator reviewed · 65 structured indications
- Formula / weight
- C10H20O · 156.2652 g/mol (avg)
- First approval
- Canada, 1996 · United States, 2007
- Also known as
- (-)-(1R,3R,4S)-MENTHOL · (-)-MENTHYL ALCOHOL · (-)-TRANS-P-METHAN-CIS-3-OL · (1R,2S,5R)-(-)-MENTHOL · (1R,2S,5R)-2-ISOPROPYL-5-METHYLCYCLOHEXAN-1-OL
- Code names
- FEMA NO. 2665, (-)- · NPO-11 · NSC-62788
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
NOOLISFMXDJSKH-KXUCPTDWSA-NSMILESCC(C)[C@@H]1CC[C@@H](C)C[C@H]1OWhat you can answer from here — as of September 23, 2026
5Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Levomenthol, and which of those have an active Phase 3 trial?
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