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Dexloxiglumide
go.drugbank.com/drugs/DB04856InvestigationalDexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist in phase III testing by Rottapharm in Europe only, as U.S. trials have been discontinued. … As the D-isomer of loxiglumide, it retains all pharmacological properties of loxiglumide but is more potent.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesLefradafiban
go.drugbank.com/drugs/DB04863InvestigationalLefradafiban is an oral platelet glycoprotein IIb/IIIa receptor antagonist being investigated in the treatment of angina.
Categories: Heterocyclic Compounds, 1-RingLintitript
go.drugbank.com/drugs/DB04867ExperimentalLintitript is a new, highly specific and potent CCK-A receptor antagonist.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingPicoplatin
go.drugbank.com/drugs/DB04874InvestigationalPicoplatin is a cytotoxic platinum compound in clinical development for the treatment of patients with solid tumors.
Synonyms: (SP-4-3)-Amminedichloro(2-methylpyridine)platiniumPralnacasan
go.drugbank.com/drugs/DB04875ExperimentalPralnacasan is an orally bioavailable pro-drug of a potent, non-peptide inhibitor of interleukin-1beta converting enzyme (ICE).
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingVoacamine
go.drugbank.com/drugs/DB04877ExperimentalVoacamine is an alkaloid isolated from the bark of the Pescheria fuchsiae folia tree. It is an antimalarial drug approved for use in several African countries. Voacamine is also under investigation for use in modulating multidrug-resista...
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 2-RingCalanolide A
go.drugbank.com/drugs/DB04886InvestigationalCalanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. … A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared with placebo.
Synonyms: Calanolide A, (+)-calanolide ACategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingBicifadine
go.drugbank.com/drugs/DB04889InvestigationalBicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesBecocalcidiol
go.drugbank.com/drugs/DB04891InvestigationalBecocalcidiol is a vitamin D(3) analogue which has not caused hypercalcaemia or significant irritation in preclinical trials.
Categories: Vitamin D and AnaloguesAZD3409
go.drugbank.com/drugs/DB04893ExperimentalAZD3409 is a farnesyl-transferase inhibitor (FAR) indicated for the treatment of solid tumors. Phase I trials were initiated January 2003, and were ongoing as of February 2004.
Categories: Heterocyclic Compounds, 1-Ring