Voacamine

DB04877ExperimentalSmall molecule

Voacamine is an alkaloid isolated from the bark of the Pescheria fuchsiae folia tree. It is an antimalarial drug approved for use in several African countries. Voacamine is also under... Voacamine is also under investigation for use in modulating multidrug-resistance in tumor cells.

Mechanism: Voacamine is possibly a substrate for P-glycoprotein (P-gp), an efflux pump responsible for multidrug resistance in tumor cells. Voacamine may compete with anticancer drugs such as doxorubicin for P-gp transport, decreasing removal of doxorubicin.
Curator reviewed
Primary indication: For the treatment of malaria.Curator reviewed
Formula / weight: C₄₃H₅₂N₄O₅ · 704.8968 g/mol (avg)
Also known as: Voacanginine · Vocamine
Code names: MMH-18

Resolves to

Compound

UNII2Z504YT5AGCAS3371-85-5ChEMBLCHEMBL445022PubChem11953931KEGGC09252

Clinical / RWD

PharmGKBPA165958347

Structure

InChIKeyVCMIRXRRQJNZJT-XRMSBCOFSA-NSMILES

[H][C@@]12C[C@H](CC)[C@]3([H])N(C1)CCC1=C(NC4=CC(=C(OC)C=C14)[C@@]1([H])C[C@]4([H])C(C(=O)OC)[C@@]([H])(CC5=C1NC1=CC=CC=C51)N(C)C\C4=C\C)[C@@]3(C2)C(=O)OC

Targets

P08183ABCB1

Transporters

P08183ABCB1

What you can answer from here — as of October 01, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Voacamine, and which of those have an active Phase 3 trial?

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