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KP-1461
go.drugbank.com/drugs/DB05644InvestigationalDesignated a DNA covert nucleoside, the drug consists of a modified base that incorporates randomly into HIV and pairs with multiple bases. … KP-1461 is a potent, non-chain-terminating, mutagenic deoxyribonucleoside analogue.
Vapitadine
go.drugbank.com/drugs/DB05738ExperimentalVapitadine is an antihistamine that Barrier Therapeutics is developing as a treatment for allergic reactions of the skin, such as those associated with hives and for the itch associated with atopic dermatitis
Perflubron
go.drugbank.com/drugs/DB05791InvestigationalPerflubron (Oxygent) is being developed as an intravascular oxygen carrier designed to augment oxygen delivery in surgical patients.
Categories: Compounds used in a research, industrial, or household settingPrasterone sulfate
go.drugbank.com/drugs/DB05804InvestigationalDHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin. DHEA-S is elevated with hyperprolactinemia.
Categories: Cytochrome P-450 CYP3A7 SubstratesSynonyms: (3-beta)-3-(Sulfooxy)androst-5-en-17-one, 3-O-SulfodehydroepiandrosteroneAbiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigationalAbiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-Pyridyl)androsta-5,16-dien-3beta-olCiluprevir
go.drugbank.com/drugs/DB05868InvestigationalThe compound, named BILN 2061, is an orally active inhibitor of the HCV NS3 protease and the first member of this new drug class to be tested in humans.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingDenibulin
go.drugbank.com/drugs/DB05932ExperimentalDenibulin is a novel small molecule Vascular Disrupting Agent under development by MediciNova for treatment of solid tumor cancers.
Categories: Heterocyclic Compounds, 2-RingTrofinetide
go.drugbank.com/drugs/DB06045Approved1 (IGF-1). … Trofinetide is a novel synthetic analog of [glypromate], also known as glycine–proline–glutamate (GPE), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsSynonyms: glycyl-L-2-methylprolyl-L-glutamic acidTapinarof
go.drugbank.com/drugs/DB06083ApprovedInvestigational[L41845, A248790] Tapiranof was first discovered as a metabolite (3,5-dihydroxy-4-isopropylstilbene) produced in _Photorhabdus luminescens_, a gram-negative bacillus that lives symbiotically with the _ … It is available as a topical cream to be applied to the affected area once daily.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: 3,5-Dihydroxy-4-isopropyl-trans-stilbeneCenobamate
go.drugbank.com/drugs/DB06119ApprovedInvestigational[A188442,L10653] The exact mechanism of action has not been described in the literature, though it positively modulates GABA<sub>A</sub> and inhibits voltage gated sodium channels.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Inducers