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11-beta-Hydroxylase Deficiency (CYP11B1)
smpdb.ca/view/SMP0125800Disease11-beta-Hydroxylase Deficiency, also called congenital adrenal hyperplasia (CAH), is an autosomal recessive disorder and caused by a defective 11-beta-hydroxylase. 11-beta-hydroxylase catalyzes the conversion of cortexolone into cortisol...
Corticosterone Methyl Oxidase II Deficiency (CMO II)
smpdb.ca/view/SMP0125802DiseaseHowever, since progesterone and 11b-hydroxyprogesterone are both produced and used by other reactions, their levels in the cell are not changed as drastically. … It is caused by a mutation in the cytochrome P450 11B2 gene, whose protein product is responsible for the formation of aldosterone from 18-hydroxycorticosterone (18-OHB), as well as converting progesterone
Pantoprazole
go.drugbank.com/drugs/DB00213ApprovedInvestigationalPantoprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme … increased risk of developing hypomagnesemia and hypocalcemia which may contribute to osteoporosis and bone fractures later in life.
Products: PANTOPRAZOLO EG, PANTO 40 MG IV ENJ. LIYOFILIZE TOZ ICEREN FLAKONPrednisolone
go.drugbank.com/drugs/DB00860ApprovedInvestigationalVet approved[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431]
Synonyms: Predniso(lo)neProducts: AXCEL PREDNISOLONE-5MG EC TABLET, PRED UNDanazol
go.drugbank.com/drugs/DB01406ApprovedInvestigationalDanazol has been used in the treatment of endometriosis and some benign breast disorders. … A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins.
Thiocolchicoside
go.drugbank.com/drugs/DB11582InvestigationalThiocolchicoside is a semi-synthetic derivative of the colchicine, a natural anti-inflammatory glycoside which originates from the flower seeds of Superba gloriosa. It is a muscle relaxant with anti-inflammatory and analgesic effects. It...
Products: TIOCOLCHICOSIDE EG, MUSCORIL CONTRATTURE E DOLOREPravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigational[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. … [L6142] Pravastatin is made through a fermentation process in which [mevastatin] is first obtained.
Products: PRAVASTATINA EGBrexanolone
go.drugbank.com/drugs/DB11859ApprovedInvestigationalthe weaning of third-line agents and resolution of potentially life-threatening status epilepticus with brexanolone vs. placebo when added to standard-of-care [L5750]. … In particular, the use of brexanolone in treating PPD is surrounded with promise because it acts in part as a synthetic supplement for possible deficiencies in endogenous brexanolone (allopregnanolone)
Categories: Progesterone CongenersMedrogestone
go.drugbank.com/drugs/DB09124ApprovedWithdrawnIt was conceived as an alternative for an orally effective contraceptive option.[A31526] It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing.
Camizestrant
go.drugbank.com/drugs/DB19218ApprovedInvestigational[L64117,L64107,L64116] It is the first next-generation oral SERD and complete ER antagonist approved in the first-line setting, and the only one approved for use with all three widely approved CDK4/6 inhibitors … [L64094,L64107] Patients are selected for treatment on the basis of an *ESR1* mutation detected by circulating tumor DNA testing during first-line endocrine therapy, before radiographic disease progression
Synonyms: 3-pyridinamine, n-(1-(3-fluoropropyl)-3-azetidinyl)-6-((6s,8r)-6,7,8,9-tetrahydro-8-methyl-7-(2,2,2-trifluoroethyl)-3h-pyrazolo(4,3-f)isoquinolin-6-yl)-, N-(1-(3-fluoropropyl)-3-azetidinyl)-6-((6s,8r)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3h-pyrazolo(4,3-f)isoquinolin-6-yl)-3-pyridinamine