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Displaying results 6111 - 6120 of 10000 in total
  1. Drug

    RGX-181

    go.drugbank.com/drugs/DB17942
    Experimental

    RGX-181 consists of an adeno-associated virus serotype 9 (AAV9) vector designed to deliver the soluble lysosomal enzyme tripeptidyl peptidase I (TPP1) gene. … Developed by REGENXBIO, it is being investigated for the treatment of late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease.[L47072]

  2. Drug

    Zebularine

    go.drugbank.com/drugs/DB03068
    Experimental

    It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. … Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

  3. Drug

    Nacubactam

    go.drugbank.com/drugs/DB15353
    Investigational

    Nacubactam is under investigation in clinical trial NCT03174795 (A Study to Investigate the Pharmacokinetics of RO7079901 and Meropenem in Participants With a Complicated Urinary Tract Infection).

  4. Drug

    Ertumaxomab

    go.drugbank.com/drugs/DB18923
    Investigational

    Ertumaxomab is under investigation in clinical trial NCT00522457 (Phase II Study With the Trifunctional Antibody Ertumaxomab to Treat Metastatic Breast Cancer After Progression on Trastuzumab Therapy).

  5. Drug

    DA-8031

    go.drugbank.com/drugs/DB19024
    Investigational

    DA-8031 is under investigation in clinical trial NCT01798667 (Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation).

  6. Drug

    Trodusquemine

    go.drugbank.com/drugs/DB06333
    Investigational

    It has demonstrated the ability to stimulate regeneration of heart and multiple other tissues in animal models [A176600].

  7. Drug

    FT516

    go.drugbank.com/drugs/DB15732
    Investigational

    This compound expresses a high-affinity 158V, CD16 (hnCD16) Fc receptor that has an enhanced binding ability to tumor-targeting antibodies, and is resistant to downregulation. … FT516 is an investigational and engineered off-the-shelf natural killer (NK) cell therapy originating from induced pluripotent stem cells (iPSC).

  8. Drug

    IN01

    go.drugbank.com/drugs/DB16434
    Experimental

    The study will explore the effect of this vaccine on pulmonary function, oxygen saturation, quality of life, and fibrosing status in addition to biomarkers and molecular markers of the vaccine. … The IN01 Vaccine, sponsored by the Instituto Oncologico Dr Rosell, IN3BIO, and PANGAEA, is a compound containing recombinant bacteria[L30543].

  9. Drug

    Human Embryonic Stem Cell-derived M Cell

    go.drugbank.com/drugs/DB15734
    Investigational

    IMRCs are similar to MSCs in terms of their capacity for self-renewal and tri-lineage differentiation. … CAStem is composed of immunity- and matrix-regulatory cells (IMRCs), also known as M cells, which can be administered through injection.

  10. Drug

    GSK-945237

    go.drugbank.com/drugs/DB15345
    Investigational

    and Repeat Escalating Oral Doses of GSK945237; the Effect of Linezolid on Hematology Safety Parameters; and the Effects of GSK945237 and Moxifloxacin on QTc.). … GSK-945237 is under investigation in clinical trial NCT01039610 (A Single Center Four Part Study in Healthy Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose