CAStem is composed of immunity- and matrix-regulatory cells (IMRCs), also known as M cells, which can be administered through injection. These IMRCs are differentiated from human embryonic stem cells that... These cells are currently being investigated against lung injury and fibrosis -- conditions which are outcomes of lung disorders including COVID-19.
- Mechanism
- Curator reviewed
IMRCs are different from cells such as the umbilical cord mesenchymal stem cells in gene expression profile; thus, this results in IMRCs possessing qualities such as higher expression levels of proliferative, immunomodulatory, and anti-fibrotic genes. Additionally, they have the ability to modulate immunity and regulate extracellular matrix production.
- Also known as
- CAStem · immunity- and matrix-regulatory cells · Immunity-and-matrix-regulatory cells · IMRCs · M cells
- Code names
- Human Embryonic Stem Cell-derived M Cell
What you can answer from here — as of August 13, 2020
Which companies are running trials of Human Embryonic Stem Cell-derived M Cell, in which indications and phases, and which of those programs are still active?
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